Databases The following databases and respective searches were used. • Medline/PubMed: (Sweetening Agents/adverse effects OR Saccharin OR Cyclamate* OR Aspartame OR Acetosulfame OR Acesulfame) AND (Risk Factors OR Risk OR Risk Assessment OR Neoplasm* OR Carcinoma OR Cancer OR Carcinogenic) AND (Etiology/Broad[filter] OR Prognosis/Broad[filter] OR Comparative study OR Comparative studies). • Emb...

Ambient air is a complex mixture containing a variety of substances, some of which are known to be carcinogenic. To develop a homogeneous approach for regulating the emission of these compounds, their individual carcinogenic potential needs to be placed on a comparable scale. The unit risk may be considered as an appropriate measure that condensates dose-response analyses of epidemiologic data ...

BACKGROUND Loop electrosurgical excision procedure (LEEP) is the predominant treatment for cervical intraepithelial neoplasia grade 2 or 3 (CIN2+) in the United States, yet following treatment approximately 10% of women are diagnosed again with CIN2+, necessitating close follow-up of such patients. METHODS Surveillance strategies using cytology and/or human papillomavirus (HPV) testing were c...

Coal mining and related industry can increase heavy metals (HMs) concentrations in soil, atmosphere and wheat, thereby posing metal-associated human health risk via food ingestion.  In this study, 58 samples of soil, wheat, and dust were collected from Xuzhou coal mine eastern China, six kinds of HMs Pb, Cd, Cu, Zn, As and Cr were studied for their spatial distribution in wheat, enrichment in d...

Carcinogenic and systemic health effects of arsenic exposure in drinking water are well documented. This study estimated the risk associated with chronic consumption of water with high concentrations of arsenic in children and adults living in six Andean locations, in Chile. Concentrations of arsenic in the drinking water were analyzed between 2014 and 2017 based on health authority reports and...

In 1969, the International Agency for Research on Cancer (IARC) initiated a programme to evaluate the carcinogenic risk of chemicals to humans and to produce monographs on individual chemicals. The Monographs programme has since been expanded to include consideration of exposures to complex mixtures of chemicals (which occur, for example, in some occupations and as a result of human habits) and...

INTRODUCTION The objective of this study was to determine the risk factors for childhood acute lymphoblastic leukemia (ALL) and, in particular, the role of parental occupational exposure to carcinogenic and probably carcinogenic hydrocarbons before the child's conception. METHODS For this case-control study, cases were children younger than 15 years who were newly diagnosed with ALL between J...

Information on the carcinogenic potential of chemicals is primarily available for High Production Volume (HPV) products. Because of the limited knowledge gain from routine cancer bioassays and the fact that HPV chemicals are tested only, there is the need for more cost-effective and informative testing strategies. Here we report the application of advanced genomics to a cellular transformation ...

In the oil-rich Niger Delta, hydrocarbon pollution and oil spillages, gas flaring and sundry anthropogenic activities constitute sources of polycyclic aromatic hydrocarbons (PAHs), with food contamination playing a major role in human exposure. In this study we assessed PAH levels in wild and cultivated edible mushroom species consumed by the general population from the oil producing Niger Delt...

Coal mining and related industry can increase heavy metals (HMs) concentrations in soil, atmosphere and wheat, thereby posing metal-associated human health risk via food ingestion.  In this study, 58 samples of soil, wheat, and dust were collected from Xuzhou coal mine eastern China, six kinds of HMs Pb, Cd, Cu, Zn, As and Cr were studied for their spatial distribution in wheat, enrichment in d...