In the present investigation an attempt has been made to design efficacious and prolonged release mucoadhesive tablet of salbutamol sulphate using various polymers to avoid the first pass metabolism to reduce dossing frequency and to improve patient compliance. Mucoadhesive buccal tablet of salbutamol sulphate were fabricated with objective of avoiding first pass metabolism and to improve its b...

Buccal bioadhesive bilayer tablets of prochlorperazine maleate were designed and formulated by using buccoadhesive polymers such as hydroxypropylmethyl cellulose, Carbopol 934P, and sodium alginate. Physicochemical characteristics like the uniformity of weight, hardness, thickness, surface pH, drug content, swelling index, microenvironment pH, in vitro drug release, and in vivo buccoadhesion ti...

In this study hydrogels synthesized from agarose and carbomer 974P macromers were selected for their potential application in spinal cord injury (SCI) repair strategies following their ability to carry cells and drugs. Indeed, in drug delivery applications, one of the most important issues to be addressed concerns hydrogel ability to provide a finely controlled delivery of loaded drugs, togethe...

The aim of the present work was to evaluate the transdermal permeability of pentoxifylline gel in vitro and in vivo. Gel was prepared with carbomer 934 as the base, and the Wistar rat was chosen as an animal model. The effects of percutaneous enhancers on the transdermal permeability of pentoxifylline gel were investigated by in vitro permeation experiments. Cumulative permeation at different t...

Carbomers are carboxyvinylic derivatives that are widely used in the manufacture of hydrogel dosage forms. Because of their anionic nature and large number of acid groups, they tend to interact with cationic substances, and with other hydrophilic polymers containing alcohol groups. Here, we report a study of interactions between the carbomer Carbopol and the cationic drug propranolol hydrochlor...

The effect of γ-radiation dosage on the thermal stability cross-linked acrylic polymer "Carbomer-140" (СRB) was investigated. DTA, TGA, and DTG curves show multistage processes occurring in different temperature ranges heating CRB from 25 °C to 500 °C. rates decomposition were determined 40–110 °C, 180–260 260–330 330–500 In combination with results electronic structure calculations, potential ...

Nifedipin merupakan salah satu obat yang sering digunakan dalam pengobatan hipertensi dengan frekuensi penggunaan berulang kali sehari, karena itu nifedipin perlu diformulasikan bentuk sediaan lepas lambat. Banyak metode dapat untuk membuat lambat, satunya adalah dirancang tetap tinggal di lambung. Penelitian ini bertujuan mengetahui pengaruh konsentrasi natrium bikarbonat sebagai komponen effe...