Outbreak of Carbapenem-Resistant Pseudomonas aeruginosa Producing VIM-8, a Novel Metallo-Lactamase, in a Tertiary Care Center in Cali, Colombia M. P. Crespo,* N. Woodford, A. Sinclair, M. E. Kaufmann, J Turton, J. Glover, J. D. Velez, C. R. Castañeda, M. Recalde, and D. M. Livermore Group of Medical Microbiology and Infectious Diseases, Universidad Santiago de Cali, and Infectology Division and...

Carbapenems are important agents for the therapy of infections due to multidrug-resistant Pseudomonas aeruginosa; the development of carbapenem resistance hampers effective therapeutic options. To assess the mechanisms leading to resistance, 33 clinical isolates with differing degrees of carbapenem susceptibility were analyzed for the expression of the chromosomal beta-lactamase (ampC), the por...

The antagonism of the antipseudomonal activity of ceftazidime by meropenem(la) was much less than those by imipenem (2a) and panipenem (2b). To reveal the major structural features of carbapenem compounds responsible for the antagonism, we investigated the structure-activity relationships of carbapenems to their antagonism of the antipseudomonal activity of ceftazidime and to their /Mactamase-i...

Acinetobacter spp. are important nosocomial pathogens, in particular the Acinetobacter baumannii-calcoaceticus complex, which have become a global public health threat due to increasing resistance to carbapenems and almost all other antimicrobial compounds. High rates of resistance have been reported among countries in Southeast Asia, including Malaysia. In this review, we examine the antimicro...

BACKGROUND European centers (n = 226) involved in the Tigecycline Evaluation and Surveillance Trial (TEST, 2004-2014) submitted data and bacterial isolates. METHODS Minimal inhibitory concentrations and susceptibility were determined using Clinical and Laboratory Standards Institute methods and European Committee on Antimicrobial Susceptibility Testing breakpoints. RESULTS The rates of the ...

Background: Widespread use and misuse of anti-infective agents have resulted in problems of drug resistance linked to treatment of infectious diseases caused by worrisome pathogens such as Pseudomonas aeruginosa. Infections caused by Pseudomonas aeruginosa with resistance to extended spectrum β-lactams and the carbapenems is emerging and requires the identification of effective alternative anti...

BACKGROUND The aim of this study was to investigate the molecular epidemiological characteristics of metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa clinical isolates in Korea. MATERIALS AND METHODS Three hundred and twenty nine P. aeruginosa clinical isolates were collected from 23 general hospitals in Korea from March to June 2014. Species were identified by matrix-assited laser ...

months before R178, on the same farm, indicating the animal carriage of the gene, integron and plasmid (data not shown). Also recently, Acinetobacter baumannii expressing OXA-23 isolated from cattle in France was reported. 9 The occurrence of ESBLs in Enterobacteriaceae (E. coli, Klebsiella and Salmonella) isolated from food-producing animals and the increase in their prevalence is a current pr...