OBJECTIVES Carbapenem-resistant Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa are endemic in many medical centres. Because therapeutic options are limited, understanding the epidemiology and controlling the spread of these pathogens are of paramount importance. METHODS Isolates of K. pneumoniae, A. baumannii and P. aeruginosa were collected from 14 hospitals in New...

The objective of our study was to describe the molecular support of carbapenem resistance from randomly selected clinical isolates of multidrug-resistant (MDR) Acinetobacter baumannii as a pilot study from the Hamad Medical Corporation (HMC), Qatar. Results of our report will be used to study carbapenemases using molecular techniques in all isolated MDR A. baumannii. Forty-eight MDR A. baumanni...

489 la exploración abdominal, fueron normales. La pierna izquierda estaba enrojecida, caliente, a tensión, edematosa, dolorosa a la movilización, con flictenas localizadas y pulsos distales presentes. a fin de poder instaurar una rápida y adecuada antibioterapia. Bacteraemic necrotizing fasciitis with compartment syndrome caused by non O-1 Vibrio cholera. Incidence of Vibrio cholerae and relate...

BACKGROUND Multidrug-resistant organisms (MDRO) are a worldwide problem. International migration and travel facilitate the spread of MDRO. Therefore the goal of our study was to assess the risk of influx of MDRO from patients transferred to one of Central Europe's largest hospitals from abroad. METHODS A mono-centre study was conducted. All patients transferred from other countries were scree...

Mutations in crrAB genes encoding a two-component regulator involved in modifications of lipopolysaccharide were searched for among a collection of colistin-resistant Klebsiella pneumoniae isolates. Four isolates, respectively, producing carbapenemases NDM-1, OXA-181, or KPC-2 showed mutated CrrB proteins compared with those in wild-type strains. Complementation assays with a wild-type CrrB pro...

tions. To allow the database to reflect the content of the live repositories to within a useful time frame, any regular automated updates of the reference database from live repositories could label new alleles with ‘provisional’ designations prior to committee approval. As a method for identifying resistance genes from WGS data the use of a reference pseudomolecule/database may yet be supersed...

Background Reports of nosocomial infection due to carbapenem resistant Serratia spp. have become significantly more common. This resistance may be due to production of distinct carbapenemases, such as KPC [1,2]. This enzyme, initially described in Klebsiella pneumoniae isolates, has also been detected among other organisms, such as Serratia marcescens, emphasizing the global risk of interspecie...