Adoptive immunotherapy using chimeric antigen receptor (CAR) expressing T cells targeting the CD19 B lineage receptor has demonstrated marked success in relapsed pre-B-cell acute lymphoblastic leukaemia (ALL). Persisting CAR-T cells generate sustained pressure against CD19 that may drive unique mechanisms of resistance. Pre-B ALL originates from a committed pre-B cell or an earlier progenitor, ...

A vast body of literature has revealed that dysregulation of the hypothalamic-pituitary-adrenal (HPA) stress axis is associated with etiology of major depressive disorder (MDD). There are many ways that the dysregulation of the HPA axis can be assessed: by sampling diurnal basal secretion and/or in response to a stress task, pharmacological challenge, and awakening. Here, we focus on the associ...

We consider a semi-discrete car-following model and the macroscopic Aw–Rascle model for traffic flow given in Lagrangian form. The solution of the car-following model converges to a weak entropy solution of the system of hyperbolic balance laws with Cauchy initial data. For the homogeneous system, we allow vacuum in the initial data. By using properties of the semi-discrete model, we show that ...

Learning driving behavior is fundamental for autonomous vehicles to “understand” traffic situations. This paper proposes a novel method for learning a behavioral model of carfollowing using automata learning algorithms. The model is interpretable for car-following behavior analysis. Frequent common state sequences are extracted from the model and clustered as driving patterns. The Next Generati...

................................................................................................................................... 7 INTRODUCTION .......................................................................................................................... 8 NATURALISTIC DRIVING DATA ............................................................................................. 8 Dat...

We proposed an extended car-following approach on evacuation system of micro traffic. It is based on the agent model. Parameter which is owned by the agent is the velocity. We added one driving behavior in the car-following a smart driver. Characteristics of smart driver he has a concern for the distance between his vehicle with the vehicle in front of him so that he will change the speed based...

As a typical self-driven many-particle system far from equilibrium, traffic flow exhibits diverse fascinating non-equilibrium phenomena, most of which are closely related to traffic flow stability and specifically the growth/dissipation pattern of disturbances. However, the traffic theories have been controversial due to a lack of precise traffic data. We have studied traffic flow from a new pe...

We consider the reinforcement learning problem of simultaneous trajectory-following and obstacle avoidance by a radio-controlled car. A space-indexed non-stationary controller policy class is chosen that is linear in the features set, where the multiplier of each feature in each controller is learned using the policy search by dynamic programming algorithm. Under the control of the learned poli...

We propose and study a one-dimensional traffic flow cellular automaton model of high-speed vehicles with the Fukui-Ishibashi-type acceleration for all cars, and the Nagel-Schreckenberg-type (NS) stochastic delay only for cars following the trail of the car ahead. The main difference in the delay scenario between our model and the NS model is that a car with spacing ahead longer than the velocit...

Car drivers appear to reduce their driving speed in high task demand situations. Summala's [Safety Sci. 22 (1996) 103±117]; [in: J.A. Rothengatter, & E. Carbonell Vaya (Eds.), Trac and Transport Psychology: Theory and Application, Pergamon, Oxford, 1997, pp. 41±52] model of behavioural adaptation (MBA) also assumes that drivers increase speed in low task demand situations or attend to addition...