in this paper, a robust model presented is developed for hub covering flow problem in which hubs have capacity. this problem has two objective functions converting to a single-objective problem by using weighting method. firstly, the problem will be formulated in a certain case. then, by considering the demand as a non-random variable, it will be modeled by robust optimization. finally, by usin...

Hub facilities serve as switching and transshipment points in transportation and communication networks as well as in logistic systems. Hub networks have an influence on flows on the hub-to-hub links and ensure benefit from economies of scale in inter-hub transportation. The key factors for designing a successful hub-and-spoke network are to determine the optimal number of hubs, to properly loc...

Data-driven functional connectivity density (FCD) mapping is being increasingly utilized to assess brain connectomics at rest in the healthy brain and its disruption in neuropsychiatric diseases with the underlying assumption that the spatiotemporal hub distribution is stationary. However, recent studies show that functional connectivity is highly dynamic. Here we study the temporal variability...

A “hub” is an object closely surrounded by, or very similar to, many other objects in the dataset. Recent studies by Radovanović et al. indicate that in high dimensional spaces, hubs almost always emerge, and objects close to the data centroid tend to become hubs. In this paper, we show that the family of kernels based on the graph Laplacian makes all objects in the dataset equally similar to t...

Gliomas are primary brain tumors, originating from the glial cells in the brain. In contrast to the more traditional view of glioma as a localized disease, it is becoming clear that global brain functioning is impacted, even with respect to functional communication between brain regions remote from the tumor itself. However, a thorough investigation of glioma-related functional connectomic prof...

Connectivity is not distributed evenly throughout the brain. Instead, it is concentrated on a small number of highly connected neural elements that act as network hubs. Across different species and measurement scales, these hubs show dense interconnectivity, forming a core or "rich club" that integrates information across anatomically distributed neural systems. Here, we show that projections b...

Recent advances in functional connectivity methods have made it possible to identify brain hubs - a set of highly connected regions serving as integrators of distributed neuronal activity. The integrative role of hub nodes makes these areas points of high vulnerability to dysfunction in brain disorders, and abnormal hub connectivity profiles have been described for several neuropsychiatric diso...