Lymphomas are solid tumors of immune system and Non-Hodgkin Lymphomas (NHL) is the most prevalent lymphomas; with wide ranges of histological and clinical features, it is so difficult to identify them. Herein, various bioinformatics tools (such as gene differential expressions, epigenetics and protein analysis) employed to find new treatment approach for NHL based on gene expression variation b...

156 Iranian patients with primary malignant tumors of the small intestine were reviewed. Malignant lymphoma was the most common tumor type, comprising 128 patients (82%), followed by adenocarcinoma (22 patients, 14.1 %), leiomyosarcoma (4 patients, 2.56%) and carcinoid tumor (2 patients, 1.28%). Lymphomas and adenocarcinomas were primarily located in the duodenum or jejunum, whereas leiomy...

BACKGROUND Natural killer and natural killer-like T-cell lymphomas presenting in the skin usually demonstrate aggressive behavior, an angiocentric distribution and a characteristic immunophenotype. In contrast, primary cutaneous CD30+ lymphoproliferative disorders form a heterogeneous spectrum including anaplastic large cell lymphomas, the majority of which display a good prognosis. Lymphomas w...

We aimed to investigate the expression and significance of Epstein-Barr virus-latent membrane protein 1 in human immunodeficiency virus-related diffuse large B-cell lymphomas. 22 cases lymphomas samples were collected. The control group consisted 7 non-human lymphomas, 6 virus-reactive hyperplasia virus. was detected by immunohistochemistry analyzed combination with clinicopathology characteris...

Cutaneous lymphomas (CL) are the second most common extranodal non-Hodgkin’s lymphomas. Their incidence is estimated at 1/100 000 yearly. Primary CL develop by definition in the skin and remain confined to the skin for a long period of time, while secondary CL reflect cutaneous spread from disseminated primary nodal or extranodal lymphomas. Primary CL include a wide spectrum of clinically and h...

Primary cutaneous B-cell lymphomas are B-cell non-Hodgkin's lymphomas that arise in the skin. The major subtypes discerned are follicle center cell lymphomas, immunocytomas (marginal zone B-cell lymphomas), and large B-cell lymphomas of the leg. In this study, we analyzed the variable heavy chain (VH) genes of 7 of these lymphomas, ie, 4 follicle center cell lymphomas (diffuse large-cell lympho...

Cutaneous lymphomas comprise a spectrum of diseases characterized by infiltration of the skin by malignant lymphocytes. The clinical manifestations of cutaneous lymphomas vary, and they can mimic benign dermatoses, as well as nodal or visceral malignancies with cutaneous spread. Cutaneous lymphomas are divided into T-cell lymphomas and B-cell lymphomas. Cutaneous T-cell lymphomas include mycosi...

AIMS To investigate whether CD30 expression is correlated with anaplastic morphology, and whether this correlated with a better survival in large cell B cell lymphomas, as has been described for T cell lymphomas. METHODS CD30 expression was investigated using frozen sections in a series of 146 large cell B cell lymphomas. Clinical data and follow up information were collected from 25 lymphoma...

Epstein-Barr virus(EBV) has been implicated in the pathogenesis of B-lymphoproliferative disorders, T-cell lymphomas and Hodgkin's disease. In this report, we performed an in situ hybridization study on EBV genome in 10 cases of nasal non-Hodgkin's lymphoma(NHL), 20 cases of Waldeyer's ring(WR) NHL, and 20 cases of nodal NHLs to document EBV association with lymphomas in Koreans. For immunophen...