Canine melanoma is the most common oral malignant tumor reported in the field of veterinary medicine. We found that lupeol, a lupine triterpene, inhibited mouse melanoma cell growth in vitro and in vivo by inducing cell differentiation. In the present study, we examined the differentiation-inducing activities of lupeol on 4 canine melanoma cells in vitro and in vivo. The induction of canine mel...

Cardiovascular disease is a leading cause of death in both humans and dogs. Dilated cardiomyopathy (DCM) accounts for a large number of these cases, reported to be the third most common form of cardiac disease in humans and the second most common in dogs. In human studies of DCM there are more than 50 genetic loci associated with the disease. Despite canine DCM having similar disease progressio...

The newest emerging viral infection of dogs is canine circovirus. It was thought to be the cause of illness and mortality in Ohio dogs in late August/early September 2013. Canine circovirus can either be the primary infection or present in the form of co-infection with other enteric pathogens. Its role as a primary pathogen still needs to be defined. In a recent paper, Linlin et al (1) document...

In South Korea, where avian influenza virus subtypes H3N2, H5N1, H6N1, and H9N2 circulate or have been detected, 3 genetically similar canine influenza virus (H3N2) strains of avian origin (A/canine/Korea/01/2007, A/canine/Korea/02/2007, and A/canine/Korea/03/2007) were isolated from dogs exhibiting severe respiratory disease. To determine whether the novel canine influenza virus of avian origi...

Point mutations within ras proto-oncogenes, particularly within the mutational hot-spot codons 12, 13 and 61, are frequently detected in human malignancies and in different types of experimentally-induced tumours in animals. So far little is known about ras mutations in naturally occurring canine fibrosarcomas or K-ras mutations in canine melanomas. To elucidate whether ras mutations exist in t...

The regenerative potential of cardiosphere-derived cells (CDCs) for ischaemic heart disease has been demonstrated in mice, rats, pigs and a recently completed clinical trial. The regenerative potential of CDCs from dog hearts has yet to be tested. Here, we show that canine CDCs can be produced from adult dog hearts. These cells display similar phenotypes in comparison to previously studied CDCs...


 Lymphoma is a cancer arising from B or T lymphocytes that are central immune system ‎components. It one of the three most common cancers encountered in canine; ‎lymphoma affects middle-aged to older dogs and usually stems lymphatic tissues, ‎such as lymph nodes, lymphoid tissue, spleen. Despite advance management ‎canine lymphoma, better understanding subtype tumor aggressiveness still ‎...

Key Points: • To date, there are four large, single-center, retrospective epidemiologic studies that describe injury types and outcome in canine trauma patients. • Prospective and retrospective case series and case reports provide additional descriptive information on particular injury types and outcome in canine trauma patients. • There are scant clinical trials evaluating the impact of interv...

The problem of endogenous viral contamination of simian cell cultures is well-recognized and was the subject of a recent review (7). Only sporadic reports have appeared in the literature on viral contamination of canine kidney cell cultures. Among viruses recovered in kidney cultures derived from apparently normal dogs are canine hepatitis (12) and canine distemper virus (10). Spertzel et al. (...