نتایج جستجو برای: cancer cell line
تعداد نتایج: 2607178 فیلتر نتایج به سال:
Background: The use of medicinal herbs in traditional medicine has been important and many of these plants have antioxidant, anti-inflammatory, antimicrobial and anti-cancer effects. Objective: The aim of this study was to evaluate the antibacterial and anti-cancer effects of Artemisia turcomanica extract on gastric cancer cell line (AGS) and its effect on expression of cyclin D1 and cyclin E g...
Regarding the rising rate of esophageal cancer in some parts of Asia, including northern and northeastern regions of Iran, the identification of new anti-cancer compounds is essential to combat the disease. The relation between some plants metabolites and these endophytic microorganisms are well characterized. In the current study, the potentials of Ephedra endophyte bacteria for the inhibition...
Background: The MET receptor is a critical member of cancer-associated RTKs and plays an important role in different biological activities, including differentiation, migration, and cell proliferation. Methods: In this study, novel MET inhibitors were introduced and applied on esophageal squamous carcinoma cell line KYSE-30, and the level of proliferation and migration, as well as the activated...
سرطان کلورکتال، عمدتاً به عنوان سرطان روده بزرگ شناخته شده است که از رشد کنترل نشده ی سلول ها در روده بزرگ و راست روده ایجاد می شود. این سرطان سومین سرطان شایع تشخیص داده شده در جهان است و 60% موارد در کشورهای توسعه یافته تشخیص داده شده است. در تقسیم بندی سرطان کلورکتال، چهار مرحله وجود دارد که براساس میزان گسترش و پیشرفت بیماری رده بندی می شود. در مرحله ی چهارم ممکن است لنف درگیر شده و متاساز آ...
Background and purpose: Nowadays, multi-drug regimens or combination therapy are new approaches in cancer treatment that combine two or several therapeutic agents. Combination therapy aims at improving the therapeutic efficacy of anticancer drugs while reducing toxicity and preventing drug resistance. The aim of this study was to determine the synergistic effect of combined clarithromycin and d...
Background: In recent years, the number of people with cancer has increased. For this reason, different drugs have been suggested for the treatment of cancer, but none of them has resulted in complete remission. Many bio-toxins are biologically active compounds with anticancer activity. In the meantime, bee venom (BV) has a potent anti cancer and tumor effects. The aim of present study is evalu...
Background: ß-carbolines, harmaline and harmine, are the major alkaloids presenting in the seeds of the Peganum harmala L. These alkaloids are known as herbal active principals with potential use in pharmaceutical and medicine. Objectives: To assess the growth inhibitory effect of phyto-alkaloids, harmaline and harmine, on cancer cell lines. Method...
Background: Cervical cancer is the second most common female cancer worldwide. Inhibitors of apoptosis proteins (IAPs) block apoptosis; therefore, therapeutic strategies targeting IAPs have attracted the interest of researchers in recent years. Apollon, a member of IAPs, inhibits apoptosis and cell death. RNA interference is a pathway in which small interfering RNA (siRNA) or shRNA (short hairp...
Introduction: Cancer is the leading cause of death in most countries. There are several methods used to treat cancer. Doxorubicin is one of the most important chemotherapy drugs that has several side effects, such as infertility, hyperuricemia, neuropathy, and cardiomyopathy. This study aimed to evaluate the anti-cancer effects of Naja naja oxiana in comparison with doxorubicin in Hela (Human c...
Objective(s): Extracellular matrix (ECM) is composed of many kinds of glycoproteins containing glycosaminoglycans (GAGs) moiety. The research was conducted based on the N-Acetylgalactosamine (GalNAc) degradation of ECM components by α-N-acetylgalactosaminidase (Nagalase) which facilitates migration and invasion of cancer cells. This study aims to investigate the effects of Naga-shRNA downregula...
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