Background: Cancer stem cells (CSCs) are a group of tumor cells with self-renewal property and differentiation potential. CSCs play a crucial role in malignant progression of several types of tumors. However, what is still controversial is the clinicopathological relationship between Nanog marker and its prognostic value in the patients with breast cancer. The expression of Nanog in the patient...

objectives: epithelial-mesenchymal transition (emt) is a fundamental stage in cancer metastasis and the presence of vascular invasion is a strong indication of the spread of the malignant tumor cells. regulation of the emt is a complex process in which several different transcription factors are involved. eomesodermin (eomes) as a member of the t-box gene family is an important component in the...

The detection of circulating breast cancer cells in blood could be of special interest as an indicator of diagnosis and prognosis, and for the selection of treatment. In a previous report, our research group determined gene expression profiles in samples of breast cancer tissue, identifying over-expression of the BIK/NBK mRNA gene in 90% of the analyzed samples. In this paper, we analyze the BI...

Adjuvant chemotherapy has been established as standard treatment for advanced cancer among multidisciplinary therapies. A simple and instructive biomarker for therapeutic response and recurrence is needed to evaluate the therapeutic effect. Jab1/COPS5 level has been shown to be associated with tumor progression and poor outcomes in many types of cancer patients. This study aims to further evalu...

Inhibitor of apoptosis protein-like protein-2 (ILP-2) has only been detected in the testis and in lymphoblastoid cells. Although previous studies have not reported the presence of ILP-2 in breast cancer tissues, this study indicates the presence of ILP-2 in breast cancer serum samples. To validate whether ILP-2 is a novel serological biomarker for breast cancer, we conducted two-dimensional gel...

Personalized cancer medicine based on genetic profiling of individual tumors is regarded as the treatment strategy of the future. The targeted drugs for the treatment of cancer have rapidly developed. However, our understanding (at the molecular level) of the precise role that potential targets have in tumorigenesis, and the survival dependence of tumors on these components, has not progressed ...

Cervical cancer is the one of leading cause death for women worldwide. It occurs due to infection with human papilloma virus (HPV) which attacks cervix in female reproductive organs. The detecting cervical method by using pap smears and liquid based cytology (LBC) vaccinations. However, both methods are limited quickly accurately. This study aims find potential biomarkers that will be used dete...

Globally, gastric cancer is one of the most common types of cancer and is the second leading cause of cancer‑induced mortality. Early detection of gastric cancer is able to contribute to a reduction of its mortality. For early detection, more specific and sensitive biomarkers than the classic biomarkers, including carcinoembryonic antigen, carbohydrate antigen 19‑9 and C‑reactive protein, are r...

By many accounts, the brave new worlds of genomics and proteomics— and their accompanying technologies— have ushered in a new era of cancer biomarker research. Researchers in cancer detection, diagnosis, and treatment all have a vested interest in discovering these proteins and small molecules that are telltale signs of early cancer, characteristics that make a type of cancer unique, or markers...