BACKGROUND Limited data are available on the use of complementary and alternative medicine (CAM) and factors associated with use among the pediatric population in the United States. METHODS Using the 2007 National Health Interview Survey data among individuals <18 years of age (n = 9417), we compared CAM users (excluding those using vitamins and minerals) and non-CAM users. Using bivariable a...

Molecular dynamics studies of the N-domain (amino acids 1-77; CaM(1-77)) of Ca2+-loaded calmodulin (CaM) show that a solvent exposed hydrophobic cleft in the crystal structure of CaM exhibits transitions from an exposed (open) to a buried (closed) state over a time scale of nanoseconds. As a consequence of burying the hydrophobic cleft, the R(g) of the protein is reduced by 1.5 A. Based on this...

Calmodulin-binding (CAM-binding) proteins are one of the most recently studied cases of protein interactions. Calmodulin is a calcium-binding protein that is a major transducer of calcium signal that forms an intricate network of loops to control the location, amount and effect of calcium influx. CAM-binding proteins are a varied group of targets and their interactions with Calmodulin can be su...

The alpha-toxin-permeabilized betaTC3 cell has been utilized as an experimental model for the identification of protein phosphatases responsible for the dephosphorylation and deactivation of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) in situ. In this model, the elevation of Ca2+ from 0.05 to 10 microM induced the near-total conversion of CaM kinase II into a Ca2+/calmodulin-ind...

BACKGROUND This study explored the psychological and behavioral mechanisms of complementary and alternative medicine (CAM) use in Japanese cancer patients using two applied behavioral models, the transtheoretical model (TTM), and theory of planned behavior (TPB). PATIENTS AND METHODS Questionnaires were distributed to 1100 patients at three cancer treatment facilities in Japan and data on 521...

A 2.5-A resolution structure of calcium-free calmodulin (CaM) bound to the first two IQ motifs of the murine myosin V heavy chain reveals an unusual CaM conformation. The C-terminal lobe of each CaM adopts a semi-open conformation that grips the first part of the IQ motif (IQxxxR), whereas the N-terminal lobe adopts a closed conformation that interacts more weakly with the second part of the mo...

Two new ltering/diffusion operators have been implemented in the Community Atmosphere Model nite-volume dynamical core (CAM-FV). First, a fourth-order divergence damping operator has been added to optionally replace the second-order version that has traditionally been used. This provides more scale selective dissipation of divergent modes that can generate gridscale noise in CAM-FV if not dam...