The tremendous therapeutic potential of curcumin as a chemopreventive, antineoplastic and chemosensitizing agent has failed to progress towards clinical development and commercialization due to its unfavorable physicochemical properties, low aqueous solubility, chemical instability, and pharmacokinetics. The present contribution is focused on the feasibility of using PEGylated calixarene, in pa...

The title compound, 5(2)-[(5-bromo-pent-yl)-oxy]-1(2),1(14),3(5),5(5)-tetra-tert-butyl-1(7),1(8),1(9),1(10)-tetra-hydro-1(6) H,1(16) H-1(4,12)-dibenzo[b,e][1,7]dioxa-cyclo-dodecina-3,5(1,3)-dibenzena-cyclo-hexa-phan-3(2)-ol, C54H73BrO4, was synthesized from the reaction of tert-butyl-calix[4]arene with 1,5-di-bromo-pentane using K2CO3 in CH3CN. The structure consists of a calixarene unit with a...

The reaction of tetra-kis-(all-yloxy)calix[4]arene with the first-generation Grubbs catalyst, followed by catalytic hydrogenation, gave the novel bis-calixarene 15,20,46,51,64,69,74,79-octa-oxatridecacyclo[32.28.8.8(3,28).1(13,53).1(22,44).0(9,14).0(21,26).0(38,70).0(40,45).0(52,57).0(59,63).0(7,80).0(32,73)]octa-conta-1(63),3,5,7(80),9(14),10,12,21,23,25,28(73),29,31,34,36,38(70),40,42,44,52,5...

Among different types of calixarenes, the water–soluble ones are of especial interest because of their possible applications in biochemical research. In order to elucidate the nature of aqueous solutions of a cationic amphiphilic calixarene, substituted tetrapropoxy-calix[4]arene bearing hydrophilic choline groups at the upper rim, we studied vis– spectroscopically the influence of the above sy...

Vesicles 107 ± 19 nm in diameter, based on the self-assembly of tetra-para-phosphonomethyl calix[4]- arene bearing n-hexyl moieties attached to the phenolic oxygen centres, are effective in binding carboplatin within the cavity of the macrocycle under shear induced within a dynamic thin film in a continuous flow vortex fluidic device. Post shearing the vesicles maintain similar diameters and re...

The inclusion behavior of Solvent Violet 9 (SV9) with 4-sulfonatocalix[n]arenes (SCXn) (n=4,6,8) was investigated at various pH values by ultraviolet-visible spectroscopy. SV9 is able to form an inclusion complex with calixarenes. Different absorption behaviors were observed for the dye with the various host calixarenes. The molecular binding abilities were affected by the configuration of the ...

The per-ipso-nitration of a TMPA-capped calix[6]arene has been achieved. The substitution of the six bulky tBu substituents for nitro groups has a strong impact on the behavior of the ligand during guest recognition. The complexation of the aza cap (by H(+) or Cu(+)) associated with the encapsulation of a guest triggers an induced-fit process leading to the loss of the cone conformation of the ...

A long period grating (LPG) modified with a mesoporous film infused with a calixarene as a functional compound was employed for the detection of individual volatile organic compounds (VOCs) and their mixtures. The mesoporous film consisted of an inorganic part, SiO₂ nanoparticles (NPs), along with an organic moiety of poly(allylamine hydrochloride) polycation PAH, which was finally infused with...

Two novel calix[6]cryptamides bearing a tren-based cap have been synthesized and their host-guest properties have been investigated by (1)H and (19)F NMR spectroscopy. One of them behaves as a remarkable heteroditopic receptor toward either polar neutral guests, anions or contact ion pairs. It has been shown that only F(-) can be encapsulated into the tris-amido cap of this host. Moreover, the ...