In this project, eggshell membrane was used as a solid phase extraction sorbent for extraction of morphine followed by HPLC analysis. At first, raw eggshell membrane was used and then, because of low adsorption of morphine on untreated eggshell membrane (<70%), modification of eggshell membrane surface was carried out using different surfactants and amines. The amine modified eggshells characte...

BACKGROUND Microplate-based thrombin generation test (TGT) is widely used as clinical measure of global hemostatic potential and it becomes a useful tool for control of drug potency and quality by drug manufactures. However, the convenience of the microtiter plate technology can be deceiving: microplate assays are prone to location-based variability in different parts of the microtiter plate. ...

With the emergence of artesunate antimalarial counterfeiting in Southeast Asia and sub-Saharan Africa, we present the production of a rapid, inexpensive and simple colorimetric-based testing kit for the detection of counterfeit artesunate in order to preserve life and prevent the development of multi-drug resistant malaria. The kit works based on paper microfluidics which offer several advantag...

Recognition and extraction of features in a nonparametric density estimate is highly dependent on correct calibration. The data-driven choice of bandwidth h in kernel density estimation is a di cult one, compounded by the fact that the globally optimal h is not generally optimal for all values of x. In recognition of this fact, a new type of graphical tool, the mode tree, is proposed. The basic...

The aim of the present investigation was to develop a biosensor for the detection of amino acids, Leucine, Isoleucine and Valine based on a quartz crystal nanobalance. leucine (Leu), isoleucine (Ile), and valine (Val) were selectively determined by quartz crystal nanobalance (QCN) sensor in conjunction with net analyte signal (NAS)-based method called HLA/GO. An orthogonal design was applied fo...

The air comparison could use more explanation. I think the authors should comment on how reliable these results are considering that some comparisons are based on measurements of dry air, while some are based on wet air with factory water vapor corrections, which, except for QC-TILDAS, you have shown are not adequate. You mentioned that the water vapor during the third period was < 1% (winter),...

OBJECTIVES To compare implications of using the logistic EuroSCORE and a locally derived model when analysing individual surgeon mortality outcomes. DESIGN Retrospective analysis of prospectively collected data. SETTING All NHS hospitals undertaking adult cardiac surgery in northwest England. PATIENTS 14,637 consecutive patients, April 2002 to March 2005. MAIN OUTCOME MEASURES We have c...

Radiometric precision is difficult to maintain in orbital images due to several factors (atmospheric conditions, Earth-sun distance, detector calibration, illumination, and viewing angles). These unwanted effects must be removed for radiometric consistency among temporal images, leaving only land-leaving radiances, for optimum change detection. A variety of relative radiometric correction techn...

We thank Dr. Stern (1) for his interest in our work (2). We agree that risk distribution curves are a valuable addition in the assessment of risk prediction models, particularly in the interpretation of reclassification measures. Two identical risk distribution curves that differ in location reflect models with different calibration, and 2 risk distribution curves that differ in dispersion refl...