Amyloid deposits in the islets of Langerhans of the pancreas are a common finding in non-insulin-dependent diabetes mellitus. The main protein constituent of these deposits is a 37-amino acid peptide known as amylin that resembles calcitonin gene-related peptide, a neuropeptide. We have isolated cDNA clones corresponding to the rat amylin precursor from an islet cDNA library and we show that th...

Abstract Calcitonin gene related peptide (CGRP) expressing neurons in the parabrachial nucleus have been shown to encode danger. Through projections amygdala and other forebrain structures, they regulate food intake trigger adaptive behaviors response threats like inflammation, intoxication, tumors pain. Despite fact that this danger-encoding neuronal population has defined based on its CGRP ex...

Atopic dermatitis (AD) is an often severely pruritic chronic inflammatory disease worsened by psychological stress. Calcitonin gene-related peptide (CGRP) a sensory neuropeptide, which may cause pruritus. Earlier studies indicate special pathogenetic role for CGRP in AD. However, somewhat contradictory results regarding positive nerve fibers AD skin, have been reported. We studied skin biopsies...

We examined the effects of the histamine H2-receptor antagonist, lafutidine, on the levels of gastrointestinal peptides (somatostatin, calcitonin gene-related peptide (CGRP), gastrin, secretin, and motilin) in plasma from healthy subjects. After a single oral administration of lafutidine (10 mg), the plasma lafutidine level (186 +/- 13.4ng/ml) was highest in the 60-min sample after administrati...

Objective(s) Recent studies on human indicate that the introduction of therapeutic use of tolerogenic dendritic cell (DC) for chronic inflammatory conditions is imminent. For the purpose of defining CGRP potency in tolerogenic DC production, we investigated the phenotype and IL-'2 production of DCs generated from the monocytes of rheumatoid arthritis (RA) patients in the presence of the calcit...