To address questions about sex assignment in children with ambiguous genitalia, we studied gender identity in girls with congenital adrenal hyperplasia (CAH) in relation to characteristics of the disease and treatment, particularly genital appearance and surgery. A 9-item gender identity interview was administered to 43 girls with classical CAH ranging in age from 3-18 yr, 7 tomboys, and 29 sis...

BACKGROUND Congenital adrenal hyperplasia (CAH) and vanishing testes are uncommon diseases that can result from hormonal and mechanical factors. Classic CAH is determined by ambiguous genitalia and increase in amount of 17-Hydroxyprogesterone. Simultaneous occurrence of CAH and vanishing testes is a rare condition. CASE A 22-year-old boy, known case of CAH who was diagnosed as female pseudohe...

UNLABELLED The study was aimed to find out the prevalence of non-classical congenital adrenal hyperplasia (NC-CAH) due to 21-hydroxylase deficiency (21-OHdef) among Greek women with hirsutism and polycystic ovary syndrome (PCOS) and to compare the results of ACTH stimulated 17-hydroxyprogesterone 60 min (17-OHP60) values, with human leukocyte antigens (HLA) phenotypes, in any patient diagnosed ...

CONTEXT In congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency, a strong genotype-phenotype correlation exists in childhood. However, similar data in adults are lacking. OBJECTIVE The objective of the study was to test whether the severity of disease-causing CYP21A2 mutations influences the treatment and health status in adults with CAH. RESEARCH DESIGN AND METHODS We anal...

A formamide molecule is allowed to form a CH O H-bond with a glycine dipeptide in both its C5 and C7 internal conformations. As this intermolecular H-bond is elongated, the contraction of the CAH covalent bond is monitored, as is its vibrational stretching frequency and intensity, along with NMR chemical shifts of the atoms involved in the H-bond. The degree of shortening of the CAH bond become...

The optimum treatment of chronic active hepatitis (CAH) is unknown. Various immunosuppressive agents have been used in the past. The use of prednisolone has been found to be beneficial in patients with severe chronic active hepatitis. The criteria for treatment remain uncertain. Long term follow-up of chronic active hepatitis of moderate severity treated with prednisolone showed that hepatitis ...

Introduction Congenital Adrenal Hyperplasia (CAH) is a life threatening requiring good parental knowledge, in order to manage the daily care and any clinical problems arise. The impact of the condition is significant regardless of cultural background, with near death experiences and genital ambiguity occurring. Parents need to adjust to the burdens, that having a child with CAH creates, for all...

Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder characterized by enzyme defects in the steroidogenic pathways. Testicular adrenal rest tumors (TARTs) are may have serious consequences in patients with CAH. They probably develop from ectopic remnants of intratesticular adrenal tissue, which might be stimulated by the rise of adrenocorticotropic hormone (ACTH). Their histo...

Congenital Adrenal Hyperplasia (CAH) is a hereditary disorder that can cause a huge impact to the sufferer, his family and surrounding living environment but is still often diagnosed late. We believe that a better understanding of the disease through analysis of the chief complaints and early signs of CAH will aid early diagnosis. Analysis of chief complaints and early signs of CAH from paediat...

Congenital adrenal hyperplasia (CAH) during pregnancy is a rare condition. Only a few cases have been reported in the literature. CAH patients has lower pregnancy rate compared to normal women. A 27-year-old nulliparous woman, a diagnosed case of 21-hydroxylase deficient simple virilising form of classic CAH visited. She got pregnant spontaneously without any trial of assisted reproductive tech...