نتایج جستجو برای: caga

تعداد نتایج: 1734  

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008
Margarita Camorlinga-Ponce Lourdes Flores-Luna Eduardo Lazcano-Ponce Rolando Herrero Fernando Bernal-Sahagún Juan Miguel Abdo-Francis Jesús Aguirre-García Nubia Muñoz Javier Torres

OBJECTIVE The course of Helicobacter pylori infection and antibody response to CagA in patients with preneoplastic lesions and gastric cancer has not been thoroughly studied. We aimed to study H. pylori infection and antibody response to CagA in patients with non-atrophic gastritis, preneoplastic lesions, and gastric cancer. METHODS We studied patients attending one Oncology Hospital and one ...

Journal: :Infection and immunity 2007
Adriana Reyes-Leon John C Atherton Richard H Argent J L Puente J Torres

Helicobacter pylori CagA is translocated into gastric epithelial cells by a type IV secretion system and interacts with the Src homology 2 phosphatase, altering cell morphology. Multiple EPIYA motifs in CagA are associated with increased activity in cells and with gastric cancer. The aim of this work was to study the heterogeneity in activity in cells of multiple H. pylori single colonies isola...

2014
Hashem FakhreYaseri Mehdi Shakaraby Hamid Reza Bradaran Seyed Kamran Soltani Arabshahi Ali Mohammad Fakhre Yaseri

BACKGROUND The cag pathogenicity island includes a number of genes, including cytotoxin-associated protein A (cagA) and vacuolating cytotoxin (vacA) genotypes, which are associated with bacterial virulence. Although the role of cagA and vacA in the virulence of Helicobacter pylori (H. pylori) is well-established in epidemiological studies, the relationship between the cagA and vacA genotypes in...

2011
Masahide Watada Seiji Shiota Osamu Matsunari Rumiko Suzuki Kazunari Murakami Toshio Fujioka Yoshio Yamaoka

BACKGROUND Specific genotypes of several virulence factors of Helicobacter pylori (eg, cagA-positive, vacA s1, oipA "on" and babA-positive) have been reported to be predictors of severe clinical outcomes. Importantly, the presence of these genotypes correlates with each other. We hypothesized that novel virulence genes correlate with the presence of cagA. Therefore, we aimed to find novel candi...

Journal: :Arquivos de gastroenterologia 2014
Juliana Ghisleni de Oliveira Cristina Helena Targa Ferreira Anna Carolina Saraiva Camerin Cláudia Augustin Rota Luíse Meurer Themis Reverbel da Silveira

CONTEXT Helicobacter pylori (H. pylori) has a worldwide distribution, but the prevalence of infection, virulence factors, and clinical presentation vary widely according to the studied population. In Brazil, a continental country composed of several ethnicities and cultural habits, the behavior of infection also appears to vary, as many other studies have shown. OBJECTIVES Describe the preval...

2014
Faisal Aziz Xin Chen Xuesong Yang Qiu Yan

Helicobacter pylori vacA and cagA genes have significant genetic heterogenicity, resulting in different clinical outcomes. Northeast part of China has reported high prevalence of H. pylori infections and gastric cancer. Hence, we investigated the H. pylori cagA and vacA genotypes with clinical outcomes in Northeast China. Gastric tissue samples (n = 169), chronic gastritis (GIs), gastric ulcer ...

Journal: :Turkish journal of medical sciences 2014
Ceren Erdoğdu Zeynep Saribaş Yakut Akyön Yilmaz

AIM The cagA and vacA profiles and their association with clinical findings show a distinct geographical distribution. In the present study, we aimed to determine the cagA status and vacA allelic subtypes in strains isolated from a university hospital in Ankara and to evaluate their associations with histopathological and endoscopic findings. MATERIALS AND METHODS A total of 120 H. pylori str...

Journal: :Cancer research 1995
M J Blaser G I Perez-Perez H Kleanthous T L Cover R M Peek P H Chyou G N Stemmermann A Nomura

To determine whether infection with a Helicobacter pylori strain possessing cagA is associated with an increased risk of development of adenocarcinoma of the stomach, we used a nested case-control study based on a cohort of 5443 Japanese-American men in Oahu, Hawaii, who had a physical examination and a phlebotomy during 1967 to 1970. We matched 103 H. pylori-infected men who developed gastric ...

Journal: :Advanced pharmaceutical bulletin 2013
Reza Ghotaslou Morteza Milani Mohammad Taghi Akhi Mohammad Reza Nahaei Alka Hasani Mohammad Saeid Hejazi Mohammad Meshkini

PURPOSE The purpose of this research was to analyze cagA and vacA genotypes status in H. pylori isolates and relationship with clinical outcomes. METHODS Gastric biopsy specimens were cultured for H. pylori isolation and cagA and vacA genes were detected in these isolates. Data were collected and the results were analyzed using χ2 and Fishers exact tests by SPSS software version. 16. RESULT...

2014
Abdullah Özgür Yeniova Metin Kucukazman Naim Ata Kursat Dal Ayşe Kefeli Sebahat Başyiğit Bora Aktaş Kadir Okhan Akın Yaşar Nazlıgül

UNLABELLED H. pylori is related to various gastrointestinal diseases. β₂ Microglobulin (β 2M) is an intrinsic element of major histocompatibility complex (MHC I). Serum β₂M level may increase in inflammatory states. The aim of current study is to evaluate the relationship between β₂M and H. pylori bearing CagA strains. METHODS H. pylori status was determined by histopathology of samples taken...

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