Ca(2+) is an important second messenger in plant signal transduction pathways regulating stress-induced gene expression. Functional analysis of plant proteins containing Ca(2+)-binding domains (C2 domains) will help us understand the mechanisms behind the role of transcriptional regulators in the Ca(2+) signalling pathway and open new perspectives for crop genetic improvement. We identified a n...

Mucopolysaccharidosis I (MPS I) and MPS VII are due to deficient activity of the glycosaminoglycan-degrading lysosomal enzymes alpha-L-iduronidase and beta-glucuronidase, respectively, and result in abnormal bones and joints. Here, the severity of skeletal disease in MPS I and MPS VII dogs and the effects of neonatal gene therapy were evaluated. For untreated MPS VII dogs, the lengths of the se...

Although gene coevolution has been widely observed within individuals and between different organisms, rarely has this phenomenon been investigated within a phylogenetic framework. The Geraniaceae is an attractive system in which to study plastid-nuclear genome coevolution due to the highly elevated evolutionary rates in plastid genomes. In plants, the plastid-encoded RNA polymerase (PEP) is a ...

Comparative models of GABAA receptors composed of a1b3c2 subunits were generated using the acetylcholinebinding protein (AChBP) as a template and were used for predicting putative engineered cross-link sites between the a1 and the c2 subunit. The respective amino acid residues were substituted by cysteines and disulfide bond formation between subunits was investigated on co-transfection into hu...

Abstract. Prihartin I, Ismail AS, Sukorini H, Nursandi F, Zakia A, Farahdina FAR. 2023. Identification of bacterial isolates Tumpang and Bumiasri (East Java, Indonesia) using 16S rRNA gene sequencing screening their active compounds as a biofertilizer. Biodiversitas 24: 3338-3343. The objective the study was to identify (TPG) (BAS) screen-on biofertilizer active-compounds. Research materials us...

Technical Appendix Table 2. Enterovirus 71 strains selected for phylogenetic analysis Genogroup Origin Year Strain GenBank no. Diagnosis A USA 1970 BrCr U22521 Meningitis B1 Hungary 1978 Hungary-78 AB059815 NA B2 USA 1988 8149-AL-88 55E AF135907 NA B3 Malaysia 1997 0884-MAA-97 AY207645 NA B4 Australia 2000 9918-SYD-00 AY940106 NA B5 Sarawak 2003 SB12869-SAR-03 AY905545 NA C1 USA 1987 0915-MA-87...

Human birthweight is subject to stabilizing selection. Large babies are at risk of obstetric complications such as obstructed labour, which endangers both mother and child. Small babies are also at risk with reduced survival. Fetal growth requires remodelling of maternal spiral arteries to provide an adequate maternal blood supply to the placenta. This arterial transformation is achieved by pla...

Human birth weight is subject to stabilizing selection; babies born too small or too large are less likely to survive. Particular combinations of maternal/fetal immune system genes are associated with pregnancies where the babies are ≤ 5th birth weight centile, specifically an inhibitory maternal KIR AA genotype with a paternally derived fetal HLA-C2 ligand. We have now analyzed maternal KIR an...