3. Violence. Tempers flare and a few patients tend to become more agitated and violent in crowded conditions. Instances of violence have occurred in various ED waiting rooms over who is to be seen first, creating a hostile atmosphere. Bodily harm has occurred to both nursing staff and emergency physicians. 4. Lost " Golden Hour. " Bad outcome have resulted from overcrowded conditions. Patients ...

g-Aminobutyric acidA receptor g-subunits are important for benzodiazepine (BZD) binding and modulation of the g-aminobutyric acid-mediated Cl current. Previously, by using g2/a1 chimeric subunits, we identified two domains of the g2-subunit, Lys-41-Trp-82 and Arg-114-Asp-161, that are, in conjunction, necessary and sufficient for high-affinity BZD binding. In this study, we generated additional...

A study was conducted to determine the effect of different parasite control programs on weight gain and other measurements for stocker beef calves during the grazing season and subsequent feedlot phase of production. One hundred eighty recently weaned beef steers were purchased from a Mississippi sale barn and were allocated by restricted randomization on pretreatment weight to three treatments...

The structural basis by which agonists, antagonists, and allosteric modulators exert their distinct actions on ligand-gated ion channels is poorly understood. We used the substituted cysteine accessibility method to probe the structure of the GABAA receptor in the presence of ligands that elicit different pharmacological effects. Residues in the 1Met -Leu region of the GABA binding site were in...

Positive allosteric modulation of the GABAA receptor (GABAAR) via the benzodiazepine recognition site is the mechanism whereby diverse chemical classes of therapeutic agents act to reduce anxiety, induce and maintain sleep, reduce seizures, and induce conscious sedation. The binding of such therapeutic agents to this allosteric modulatory site increases the affinity of GABA for the agonist reco...

GABAA receptors mediate fast inhibitory neurotransmission in the central nervous system (CNS), and approximately half of these receptors contain 1 subunits. GABAA receptor 1 subunits are important for receptor assembly and specific pharmacological responses to benzodiazepines. Plasticity in GABAA receptor 1 subunit expression is associated with changes in CNS excitability observed during normal...