نتایج جستجو برای: butylhydroquinone
تعداد نتایج: 342 فیلتر نتایج به سال:
considering that the involvement of oxidative stress has been implicated in the toxicity of organophosphate insecticides, the objective of the present study was to investigate antioxidants and oxidative stress markers in the liver and kidney of wistar rats treated with chronic doses of diazinon. in addition, the effect of tert-butylhydroquinone (tbhq), a food-additive antioxidant, on attenuatio...
گونه های اکسیژن فعال و رادیکالهای آزاد طی تنفس سلولی در انسانها و موجودات هوازی دیگر تولید میشوند. این ترکیبات نقش مهمی را در بروز بعضی بیماریها مانند اختلالات عصبی، فشار خون بالا، التهاب، سرطان، دیابتها، بیماری آلزایمر و بیماری پارکینسون دارند. رادیکالهای آزاد ترکیبات ناپایداری هستند که به سرعت با دیگر مواد یا مولکولها در بدن واکنش داده و منجر به آسیب سلولی و بافتی میگردند. علاوه بر تو...
Tert-butylhydroquinone (TBHQ) is an antioxidant compound which shows multiple cytoprotective actions. We evaluated the effects of TBHQ on pathological cardiac remodeling and dysfunction induced by chronic overload. Pressure overload was created by transverse aortic constriction (TAC) in male C57BL/6 mice. TBHQ was incorporated in the diet and administered for 4 weeks. TBHQ treatment prevented l...
Tert-butylhydroquinone (tBHQ), an inducer of nuclear factor erythroid 2-related factor 2 (Nrf2), has been demonstrated to attenuate oxidative stress-induced injury and the apoptosis of human neural stem cells and other cell types. However, whether tBHQ is able to exert a protective effect against oxidative stress and the apoptosis of cardiomyocytes has not yet been determined. Thus, the objecti...
The effect of BayK 8644 on cytosolic Ca²⁺ concentrations ([Ca²⁺]i) and viability in PC3 human prostate cancer cells was explored. Fura-2 was applied to measure [Ca²⁺]i. BayK 8644 at 1-50 μM induced a [Ca2²⁺]i rise concentration-dependently. The response was reduced by removing extracellular Ca²⁺. BayK 8644-evoked Ca²⁺ entry was inhibited by nifedipine, econazole, SK&F96365, and protein kinase C...
Nowadays, RNA synthesis has become an essential tool not only in the field of molecular biology and medicine, but also in areas like molecular diagnostics and material sciences. Beyond synthetic RNAs for antisense, aptamer, ribozyme, and siRNA technologies, oligoribonucleotides carrying site-specific modifications for structure and function studies are needed. This often requires labeling of th...
BACKGROUND Nanoparticles in contact with biological fluids interact with proteins and other biomolecules, thus forming a dynamic corona whose composition varies over time due to continuous protein association and dissociation events. Eventually equilibrium is reached, at which point the continued exchange will not affect the composition of the corona. RESULTS We developed a simple and effecti...
The steady state relation between cytoplasmic Ca2+ concentration ([Ca2+]i) and force was studied in intact skeletal muscle fibers of frogs. Intact twitch fibers were injected with the dextran-conjugated Ca2+ indicator, fura dextran, and the fluorescence signals of fura dextran were converted to [Ca2+]i using calibration parameters previously estimated in permeabilized muscle fibers (Konishi and...
On the basis of a mechanistic understanding of the toxicity of the 4-aminoquinoline amodiaquine (1b), three series of amodiaquine analogues have been prepared where the 4-aminophenol "metabolic alert" has been modified by replacement of the 4'-hydroxy group with a hydrogen, fluorine, or chlorine atom. Following antimalarial assessment and studies on mechanism of action, two candidates were sele...
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