Fourteen vitamin A compounds and analogs have been evaluated as inhibitors of microsomal mixed-function oxi dases from liver and lung tissues of mice and hamsters. With liver microsomes, benzo(a)pyrene (BP) is metabolized, by one pathway, to a product (BP-X) which is tightly bound to reaction components. The Km for BP in this reaction is 10 ± 2 /xM.The formation of BP-X is strongly inhibited b...

The catechin (-)-epigallocatechin-3-gallate (EGCG) exhibits high antioxidant activity and it has been reported to provide protection of the skin against damage induced by solar UV radiation. However, EGCG is highly unstable under sunlight. The present study aimed to compare the effectiveness of the co-antioxidant agents vitamin E, butylated hydroxytoluene, vitamin C and a-lipoic acid for their ...

Background: Cucurbita maxima known as pumpkin belongs to the family Cucurbitaceae, widely used in traditional medicine. Methods: The present work evaluates antioxidant activity of different parts (leaves and fruit) maxima. Antioxidant was assessed through DPPH test β-carotene bleaching test. Result: results showed that ethanolic extract fruit leaves are rich polyphenols, flavonoids tannin with ...

Epidemiological and experimental data have suggested that some micronutrients, including various carotenoids, retinoids, and alpha-tocopherol, may have chemopreventive activity against certain types of human cancer. In order to define the role of these micronutrients in cancer prevention, it is necessary to measure their concentrations in the target tissues, since these are critical to the chem...

The pork was pasteurised in jars 4 formulations: control (C), with the addition of chilli peppers (CHP), sodium ascorbate (SA), and butylated hydroxytoluene (BHT), stored at 5 °C for 50 days. Although did not slow down lipid oxidation pork, this product had lower lightness higher redness yellowness than other products. It also characterised by lowest hardness chewiness values. Sensory evaluati...

Inducible nitric oxide synthase (iNOS) content is elevated in human lung adenocarcinomas, and lung cancer patients exhale more nitric oxide (NO) than healthy individuals. The mechanism of this association of chronically elevated NO with tumorigenesis has not been defined. We investigated the role of iNOS in murine lung tumorigenesis, a model of human lung adenocarcinoma, using wild-type ( / ) a...

Induced and constitutive microsomal enzymes of mouse and hamster lungs catalyze both the hydroxylation of benzo(alpha)pyrene and reactions that lead to its irreversible binding to macromolecules. For mouse and hamster, the induced lung hydroxylases have Km values of 1.10 and 0.52 muM, respectively. The induced hydroxylases are strongly inhibited by 7,8-benzoflavone and are stimulated by cyclohe...

Inducible nitric oxide synthase (iNOS) content is elevated in human lung adenocarcinomas, and lung cancer patients exhale more nitric oxide (NO) than healthy individuals. The mechanism of this association of chronically elevated NO with tumorigenesis has not been defined. We investigated the role of iNOS in murine lung tumorigenesis, a model of human lung adenocarcinoma, using wild-type (+/+) a...