Studies in our laboratory have previously demonstrated in hamsters a superior cholesterol-lowering ability of plant sterol (PS) esters enriched in stearate compared with linoleate. We therefore conducted a randomized, double-blind, 2-group parallel, placebo-controlled study to test the cholesterol-lowering properties of stearate-enriched PS esters in normo- and hypercholesterolemic adults. Thir...

Weisiger, Richard A. Saturable stimulation of fatty acid transport through model cytoplasm by soluble binding protein. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G109–G119, 1999.—To better define the role of soluble binding proteins in the cytoplasmic transport of amphipathic molecules, we measured the diffusional mobility of a fluorescent long-chain fatty acid, 12-N-methyl-(7-nitro...

Radioactive 2-hydroxystearic and cerebronic acids were converted to the coensyme A thio esters, then tested for reactivity with n-sphingosine. Microsomes from mouse brain were found to catalyze the formation of ceramides containing both hydroxy acids. Both the Dand L-forms of the hydroxy acids reacted. Comparisons of reactivity were made with stearoyl and lignoceroyl CoA, the analogous nonhydro...

Studies were undertaken investigating improvements to the biological interaction of polymeric implant materials through their coating with an osteoinductive calcium phosphate (CaP)-type film using biomimetic deposition technology. Past research indicates that CaP coatings on implant materials increase bone growth and remodeling rates as well as enhance the stability of the bone-implant interfac...

A B S T R A C T Normal plasma has been found to inhibit the platelet aggregation-inducing effect of collagen in a time consuming reaction independent of temperature. Collagen treated with serum and washed has reduced reactivity which can be restored to normal by treatment with 1.5 M sodium chloride. On the basis of this result, it is suggested that inhibition results from adsorption to collagen...

Saturated fatty acids ranging from 15 to 20 carbons in Mkyl chain length and some stearic acid derivatives were spread as insoluble monomoleeular films and compressed at a constant velocity. As these surface films assume close packing, they exhibit a loss in surface pressure when held at constant area below an apparent collapse pressure which is not due to dissolution into the subphase solution...

Soybean oil has a wide variety of uses, and stearic acid, which is a relatively minor component of soybean oil is increasingly desired for both industrial and food applications. New soybean mutants containing high levels of the saturated fatty acid stearate in seeds were recently identified from a chemically mutagenized population. Six mutants ranged in stearate content from 6-14% stearic acid,...

Diabetes mellitus, obesity, and dyslipidemia increase risk for cardiovascular disease, and expose the heart to high plasma fatty acid (FA) levels. Recent studies suggest that distinct FA species are cardiotoxic (e.g., palmitate), while others are cardioprotective (e.g., oleate), although the molecular mechanisms mediating these observations are unclear. The purpose of the present study was to i...

The distribution of 14C in the unsaponifiable (neutral) and saponifiable (acidic) components of tissue lipids was examined 4, 24, and 72 hours after the subcutaneous injection of [2-14C]mevalonate into g-day-old rats. Of the total radioactivity contained in the unsaponifiable plus saponifiable material, 7 to 33% was in the acidic fraction obtained from the brain, spinal cord, and the skin, most...

Regioselective labelling of arene rings via electrophilic exchange is often dictated by the electronic environment caused by substituents present on the aromatic system. Previously, we observed the presence of a t-butyl group, either covalently bond or added as an external reagent, could impart deuterium exchange to the unactivated, C1-position of estrone. Here, we provide nuclear magnetic reso...