نتایج جستجو برای: bumetanide
تعداد نتایج: 859 فیلتر نتایج به سال:
This study was designed to assess the relative importance of Cl(-) and HCO(3)(-) secretion to mucociliary transport rate (MCT) in ex vivo porcine tracheas. MCT was measured in one group of tissues that was exposed to adventitial HCO(3)(-)-free solution while a parallel group was exposed to adventitial HCO(3)(-)-replete solution. After measurement of baseline MCT rates, acetylcholine (ACh) was a...
The aim of the present work was to determine the changes in ion transport in the selected epithelium-lined organs under influence of mechanical stimuli, and also to assess similarities and differences in reactions to capsaicin and dimethyl sulfoxide (DMSO) between trachea and caecum of rabbit and the skin of frog in this experimental setup. The experiments were conducted on rabbit trachea and c...
OBJECTIVE To develop an in vitro model under conditions that highly resemble the in vivo situation for searching new therapeutics targeting invasive glioma cells. MATERIALS AND METHODS We generated organotypic brain slice "co-cultures" (OBSC) from mice and cultured the models on Millicell-CM membrane inserts. U251MG glioma cells expressing enhanced green fluorescent protein (EGFP) were establ...
During development, activation of Cl -permeable GABAA receptors (GABAA-R) excites neurons as a result of elevated intracellular Cl levels and a depolarized Cl equilibrium potential (ECl). GABA becomes inhibitory as net outward neuronal transport of Cl develops in a caudal-rostral progression. In line with this caudal-rostral developmental pattern, GABAergic anticonvulsant compounds inhibit moto...
BACKGROUND/AIMS Vasoconstrictor-induced rhythmic contraction of arteries or veins has been observed both in vivo and in vitro. Many studies have reported that gap junctions, ryanodine receptors, Na+, K+-ATPase and other factors are involved in vasoconstrictor-induced rhythmic contraction in vascular smooth muscle. However, the mechanism is still not completely understood. METHODS We used vess...
Cerebral palsy is a common birth disorder that frequently involves ischemic-type injury to developing white matter (WM). Dead glial cells are a common feature of this injury and here we describe a novel form of acute ischemic cell death in developing WM astrocytes. Ischemia, modeled by the withdrawal of oxygen and glucose, evoked [Ca]i increases and cell death in astrocytes in post-natal day 10...
Effect of selective blockers of sodium and chloride ion transport (amiloride and bumetanide) on transepithelial electrical potential (PD), transepithelial electrical potential difference (dPD), and electrical resistance of the tissue (R) of isolated fragment of the rabbit's caecum were determined using electrophysiological methods designed for measuring ionic currents occurring in epithelial ti...
Cognitive dysfunction is an important aspect of the clinical characteristics of autism; however, research has often focused on social cognition. Learning and memory disorders often occur in autistic children, which are particularly under examined. Using cognitive and behavioral measures in our study, these disorders were endorsed in a valproate-induced rat model of autism. We identified increas...
The Na-K-2Cl cotransporter 2 (NKCC2) was thought to be kidney specific. Here we show expression in the brain hypothalamo-neurohypophyseal system (HNS), wherein upregulation follows osmotic stress. The HNS controls osmotic stability through the synthesis and release of the neuropeptide hormone, arginine vasopressin (AVP). AVP travels through the bloodstream to the kidney, where it promotes water...
Cerebral palsy is a common birth disorder that frequently involves ischemic-type injury to developing white matter (WM). Dead glial cells are a common feature of this injury and here we describe a novel form of acute ischemic cell death in developing WM astrocytes. Ischemia, modeled by the withdrawal of oxygen and glucose, evoked [Ca2+]i increases and cell death in astrocytes in post-natal day ...
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