BACKGROUND Mycobacterium ulcerans infection, commonly known as Buruli ulcer (BU), is a debilitating neglected tropical disease. Its management remains complex and has three main components: antibiotic treatment combining rifampicin and streptomycin for 56 days, wound dressings and skin grafts for large ulcerations, and physical therapy to prevent functional limitations after care. In Benin, BU ...

Reactions of unbridged zirconocene dichlorides, (R(n)C(5)H(5-n))(2)ZrCl(2) (n = 0, 1, or 2), with diisobutylaluminum hydride (HAl(i)Bu(2)) result in the formation of tetranuclear trihydride clusters of the type (R(n)C(5)H(5-n))(2)Zr(mu-H)(3)(Al(i)Bu(2))(3)(mu-Cl)(2), which contain three [Al(i)Bu(2)] units. Ring-bridged ansa-zirconocene dichlorides, Me(2)E(R(n)C(5)H(4-n))(2)ZrCl(2) with E = C or...

Photoacoustic imaging (PA imaging or PAI) has shown great promise in the detection and monitoring of cancer. Although nanocarrier-based contrast agents have been studied for use in PAI, small molecule contrast agents are required due to their ease of preparation, costeffectiveness, and low toxicity. Here, we evaluated the usefulness of a novel cyanine dye IC7-1-Bu as a PAI contrast agent withou...

A model for the analysis of multistage switches based on shared bu!er switching for Asynchronous Transfer Mode (ATM) networks is developed, and the results are compared with the simulation. Switches constructed from shared bu!er switches do not su!er from the head of line blocking which is the common problem in simple input bu!ering. The analysis models the state of the entire switch and extend...

Facile methoxymethylation of N(2)-derived nitride NMo(N[(t)Bu]Ar)(3) provided the imido cation [MeOCH(2)NMo(N[(t)Bu]Ar)(3)](+) as its triflate salt in 88% yield. Treatment of the latter with LiN(SiMe(3))(2) provided blue methoxyketimide complex MeO(H)CNMo(N[(t)Bu]Ar)(3) in 95% yield. Conversion of the latter to the terminal cyanide complex NCMo(N[(t)Bu]Ar)(3), which was the subject of a single-...

In this paper we study the problem of the optimal design of bu er management policies for a shared memory ATM switch or demultiplexer fed by tra c containing two different space priorities. We present the properties of the optimal policy within the class of pushout and expelling policies that minimizes total weighted cell loss. A numerical study of the optimal policies for small bu er sizes bas...

BACKGROUND Mycobacterium ulcerans disease (Buruli ulcer) is the most widespread mycobacterial disease in the world after leprosy and tuberculosis. How M. ulcerans is introduced into the skin of humans remains unclear, but it appears that individuals living in the same environment may have different susceptibilities. OBJECTIVES This study aims to determine whether frequent contacts with natura...

Öz. Kitle Kaynaklı Çalışma (KKÇ) ve Bulut Bilişim bilgi teknolojilerinde önem kazanan kavramlar arasında yer almaktadır. İnsan ve makine bulutlarının karma kullanımıyla bir sinerji oluşturulması ve bu şekilde iki dünyanın güçlü tarafları öne çıkarılırken zayıf noktalarının da üstesinden gelinmesi mümkün kılınabilir. Bu makale Orta Doğu Teknik Üniversitesi’nde kullanılmakta olan, ancak kullanım ...

Invasive punch or incisional skin biopsy specimens are currently employed for the bacteriological confirmation of the clinical diagnosis of Buruli ulcer (BU), a cutaneous infectious disease caused by Mycobacterium ulcerans. The efficacy of fine-needle aspirates (FNA) using fine-gauge needles (23G by 25 mm) for the laboratory confirmation of BU was compared with that of skin tissue fragments obt...

In a previous paper [3], one of the authors, gave a worst-case analysis for the Early Packet Discard (EPD) technique for maintaining packet integrity during overload in ATM switches. This analysis showed that to ensure 100% goodput during overload under worst-case conditions, requires a bu er with enough storage for one maximum length packet from every active virtual circuit. This paper re nes ...