نتایج جستجو برای: btk expression

تعداد نتایج: 873168  

Journal: :Blood 2014
Jennifer A Woyach Engin Bojnik Amy S Ruppert Matthew R Stefanovski Virginia M Goettl Kelly A Smucker Lisa L Smith Jason A Dubovsky William H Towns Jessica MacMurray Bonnie K Harrington Melanie E Davis Stefania Gobessi Luca Laurenti Betty Y Chang Joseph J Buggy Dimitar G Efremov John C Byrd Amy J Johnson

Chronic lymphocytic leukemia (CLL) is characterized by constitutive activation of the B-cell receptor (BCR) signaling pathway, but variable responsiveness of the BCR to antigen ligation. Bruton's tyrosine kinase (BTK) shows constitutive activity in CLL and is the target of irreversible inhibition by ibrutinib, an orally bioavailable kinase inhibitor that has shown outstanding activity in CLL. E...

Journal: :Blood 2000
A Oda Y Ikeda H D Ochs B J Druker K Ozaki M Handa T Ariga Y Sakiyama O N Witte M I Wahl

Stimulation of the platelet nonintegrin collagen receptor, glycoprotein VI, evokes a signaling response similar to that induced by antigen receptor activation in B and T lymphocytes. A key transducer of the lymphocyte signaling pathways is the Bruton's tyrosine kinase (Btk)/Tec kinase family, which connects receptors to the elevation of intracellular-free calcium levels. An important signaling ...

2015
Qi Wang Erik M Vogan Laura M Nocka Connor E Rosen Julie A Zorn Stephen C Harrison John Kuriyan

Bruton's tyrosine kinase (Btk), a Tec-family tyrosine kinase, is essential for B-cell function. We present crystallographic and biochemical analyses of Btk, which together reveal molecular details of its autoinhibition and activation. Autoinhibited Btk adopts a compact conformation like that of inactive c-Src and c-Abl. A lipid-binding PH-TH module, unique to Tec kinases, acts in conjunction wi...

Journal: :Cancer research 2016
Andrew Stiff Prashant Trikha Robert Wesolowski Kari Kendra Vincent Hsu Sarvani Uppati Elizabeth McMichael Megan Duggan Amanda Campbell Karen Keller Ian Landi Yiming Zhong Jason Dubovsky John Harrison Howard Lianbo Yu Bonnie Harrington Matthew Old Sean Reiff Thomas Mace Susheela Tridandapani Natarajan Muthusamy Michael A Caligiuri John C Byrd William E Carson

Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immature myeloid cells that expand in tumor-bearing hosts in response to soluble factors produced by tumor and stromal cells. MDSC expansion has been linked to loss of immune effector cell function and reduced efficacy of immune-based cancer therapies, highlighting the MDSC population as an attractive therapeutic target. Ibrut...

2018
Anna Tankiewicz-Kwedlo Justyna Magdalena Hermanowicz Tomasz Domaniewski Krystyna Pawlak Małgorzata Rusak Anna Pryczynicz Arkadiusz Surazynski Tomasz Kaminski Adam Kazberuk Dariusz Pawlak

BACKGROUND AND PURPOSE Bruton's tyrosine kinase (Btk) is a non-receptor tyrosine kinase involved in the activation of signalling pathways responsible for cell maturation and viability. Btk has previously been reported to be overexpressed in colon cancers. This kind of cancer is often accompanied by anaemia, which is treated with an erythropoietin supplement. The goal of the present study was to...

2017
Joo Hyun Kim Won Seog Kim Jung Yong Hong Kung Ju Ryu Seok Jin Kim Chaehwa Park

Epstein-Barr virus (EBV)-encoded nuclear antigen, EBNA2, expressed in EBV-infected B lymphocytes is critical for lymphoblastoid cell growth. Microarray profiling and cytokine array screening revealed that EBNA2 is associated with upregulation of the chemokines CCL3 and CCL4 in lymphoma cells. Depletion or inactivation of CCL3 or CCL4 sensitized DLBCL cells to doxorubicin. Our results indicate t...

Journal: :The Journal of biological chemistry 2008
Seoung Hoon Lee Taesoo Kim Daewon Jeong Nacksung Kim Yongwon Choi

A spontaneous mutation in Bruton's tyrosine kinase (Btk) induces a defect in B-cell development that results in the immunodeficiency diseases X-linked agammaglobulinemia in humans and X-linked immunodeficiency (Xid) in mice. Here we show an unexpected role of Btk in osteoclast formation. When bone marrow cells derived from Xid mice were stimulated with receptor activator of NF-kappaB ligand, an...

2016
Julie Baniszewski Emma N. I. Weeks James P. Cuda

The hydrilla tip mining midge, Cricotopus lebetis Sublette (Diptera: Chironomidae), is a biological control agent of the invasive aquatic weed hydrilla, Hydrilla verticillata (L.f.) Royle (Hydrocharitaceae). Mass rearing of the midge for augmentative releases can be compromised by competition from the adventive hydrilla leafcutter moth, Parapoynx diminutalis Snellen (Lepidoptera: Crambidae). Th...

Journal: :Journal of evolutionary biology 2007
A F Janmaat J H Myers

Pathogens are thought to exert strong selection on their hosts leading to increased host resistance. Bacillus thuringiensis kurstaki (Bkt) is a ubiquitous entomopathogen that has become the mainstay of nonchemical control of Lepidopteran pests and thus, the potential exists for the evolution of resistance in targeted host insects. We have studied the expression of Btk resistance in the cabbage ...

Journal: :The Journal of clinical investigation 2017
Meixiao Long Kyle Beckwith Priscilla Do Bethany L Mundy Amber Gordon Amy M Lehman Kami J Maddocks Carolyn Cheney Jeffrey A Jones Joseph M Flynn Leslie A Andritsos Farrukh Awan Joseph A Fraietta Carl H June Marcela V Maus Jennifer A Woyach Michael A Caligiuri Amy J Johnson Natarajan Muthusamy John C Byrd

BACKGROUND Ibrutinib has been shown to have immunomodulatory effects by inhibiting Bruton's tyrosine kinase (BTK) and IL-2-inducible T cell kinase (ITK). The relative importance of inhibiting these 2 kinases has not been examined despite its relevance to immune-based therapies. METHODS Peripheral blood mononuclear cells from chronic lymphocytic leukemia (CLL) patients on clinical trials of ib...

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