We present a case of a 75-year-old woman with right mandible cystic lesion and primary hyperparathyroidism. The MRI demonstrated marked loss of signal intensity on T2 gradient-echo images, suggesting intralesional hemossiderin. After an open biopsy, histology was consistent with "brown tumor." The finding of susceptibility on T2 gradient-echo images in a mandible lesion adds considerable specif...

The HIB 1B cell line, derived from a brown fat tumor of a transgenic mouse, is the first established brown adipocyte cell line capable of expressing the brown fat-specific mitochondrial uncoupling protein (UCP). UCP gene expression, which was virtually undetectable under basic conditions, was stimulated by acute catecholamine or cyclic AMP treatment to levels comparable to primary cultures of b...

Bone and joint pain are commonly encountered conditions in daily practice. In the elderly, when osteolytic lesions are identified in imaging studies, metastatic bone tumor is the first impression that comes to the clinician's mind. Although the worst-case scenario should be ruled in, other differential diagnoses such as metabolic bone disease should be considered as well. We report a case of br...

3. Fang GD, Yu VL, Vickers RM. Disease due to Legionellaceae (other than Legionella pneumophila): historical, microbiological, clinical and epidemiological review. Medicine (Baltimore). 1989;68:116–39. 4. Domínguez J, Galí N, Blanco S, Pedroso P, Prat C, Matas L, et al. Assessment of a new test to detect Legionella urinary antigen for the diagnosis of Legionnaire’s Disease. Diagn Microbiol Infe...

Primary hyperparathyroidism is an endocrinopathy which is characterized with the hypersecretion of parathormone. During the progress of the disease bone loss takes place due to resorption on the subperiosteal and endosteal surfaces. Brown tumor is a localized form of osteitis fibrosa cystica, being part of the hyperparathyroid bone disease. It is rarely the first symptom of hyperparathyroidism....

The patient is a seventheen years old girl, with severe pain and swelling in right maxillary sinus region and facial deformity from two weeks prior to referring. CT scan demonstrated a large tumoral mass in right maxillary sinus extended to petereigomaxillary fossa, orbital floor, lacrimal system and nasoethmoid region. Hard palate had been destroyed and bulged in to the oral cavity. Tumor was ...

Recent work by Woolley, Fekete, and Little (6, 8) has demonstrated that in certain inbred strains of mice striking changes in the adrenal cortex follow early castration. The female mice of the dilute brown (Dba) strain, castrated at birth, showed areas of nodular hyperplasia in the adrenal cortex, after one year involving and partly replacing all three zones of the cortex. These mice also showe...

Activation of brown adipose tissue (BAT) in adult humans increase glucose and fatty acid clearance as well as resting metabolic rate, whereas a prolonged elevation of BAT activity improves insulin sensitivity. However, substantial reductions in body weight following BAT activation has not yet been shown in humans. This observation raise the possibility for feedback mechanisms in adult humans in...