نتایج جستجو برای: bronchial hyperresponsiveness

تعداد نتایج: 26029  

2014
Hiroyasu Sakai Ayako Watanabe Akiko Fujita Miwa Misawa Minoru Narita Yoshihiko Chiba

Cigarette smoking is the main risk factor for the development of chronic obstructive pulmonary disease (COPD). However, little is known about the mechanisms of cigarette smoke-induced bronchial smooth muscle (BSM) hyperresponsiveness. In the present study, we investigated the effects of aqueous cigarette smoke extract (ACSE) on the BSM contraction in rats. The bronchial strips of rats were incu...

Journal: :Mediators of Inflammation 1992
R. H. Gundel H. O. Heuer L. G. Letts

The development of selective PAF receptor antagonists may provide a novel approach to the treatment of human bronchial asthma. In preclinical animal models of human asthma, PAF receptor antagonists have been found to be efficacious in blocking antigen-induced changes in lung function. However, the majority of these models involve acute inflammatory events and transient changes in lung function ...

Journal: :American journal of respiratory and critical care medicine 1998
J C Virchow P Julius M Lommatzsch W Luttmann H Renz A Braun

The mechanisms linking inflammation and airway hyperresponsiveness in allergic bronchial asthma are still not completely defined. Since neurotrophic factors increase nerve excitability and neurotransmitter synthesis and are produced by immunocompetent cells, they are likely candidates as mediators of inflammation and hyperresponsiveness. We tested the hypothesis that neurotrophin concentrations...

2014
T. Tacheva D. Dimov P. Chakarova T. Vlaykova

Bronchial asthma (BA) among children is an important health issue worldwide, including Bulgaria. The prevalence is increasing although the reasons are poorly understood. The common characteristics of asthma include bronchial spasm, airway remodeling with variable narrowing, bronchial hyperresponsiveness, and airway inflammation. One of the key pathogenetic mechanisms is the disturbance of the p...

Journal: :Arhiv za higijenu rada i toksikologiju 2007
Jovanka Karadzinska-Bislimovska Jordan Minov Snezana Risteska-Kuc Saso Stoleski Dragan Mijakoski

The aim of this cross-sectional study was to assess the prevalence and characteristics of bronchial hyperresponsiveness (BHR) in 43 women cleaners (aged 26 to 57) and 37 women cooks (aged 29 to 55) and compare them with 45 controls (women office workers aged 27 to 58). The evaluation of all subjects included a questionnaire, skin prick tests to common aeroallergens, spirometry, and histamine ch...

Journal: :Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2009
M van den Berge H I Heijink A J M van Oosterhout D S Postma

Allergic asthma is usually diagnosed by the presence of variable airway obstruction, bronchial hyperresponsiveness, and allergy. However, a significant proportion of adult asthma patients (up to 40%) are non-allergic. Patients with non-allergic asthma often have a later disease onset and greater disease severity, as reflected by more severe airway obstruction and bronchial hyperresponsiveness. ...

Journal: :Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology 1990

Journal: :American Journal of Respiratory and Critical Care Medicine 2009

Journal: :Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia 2006
Paulo Kussek Nelson Augusto Rosario Filho Mônica Cat

OBJECTIVE To assess airway hyperresponsiveness to 4.5% hypertonic saline solution in comparison to that obtained through challenge with other bronchoconstriction agents and in relation to patient allergic sensitization. METHODS A cross-sectional, experimental study was conducted, initially involving 85 subjects. After exclusions, the final sample consisted of 62 patients, divided into two gro...

Journal: :The European respiratory journal 1999
C Laprise M Laviolette M Boutet L P Boulet

To study the physiopathology and significance of asymptomatic airway hyperresponsiveness (AHR), the clinical and bronchial immunohistological parameters were evaluated in subjects with asymptomatic and symptomatic AHR. Asymptomatic subjects with AHR (eight females/two males, no respiratory symptoms, provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one ...

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