The detoxication of aromatic hydrocarbons and their halogen derivatives has been studied for many years. It has been established that these compounds undergo the biochemical reactions of oxidation to dihydrodihydroxy compounds, phe nols, and quiñones;of oxidative ring scission to form carboxylic acids; and of conjugation with cysteine to form mercapturic acids.1 With the dis covery of the carc...

Based on the core structure of diflunisal drug, herein, we report a resembling series biaryl analogs (3a–j) containing halogens, nitro, and methoxy substituents. They were designed synthesized via Suzuki–Miyaura cross-coupling reaction using Pd (OH)2 as catalyst at temperature 65 °C with an intent to obtain improved safer anti-inflammatory analgesic agents. transformation is most significant am...

The corrosion inhibitor activities of 10 molecules (Benzene (C1), Phenol (C2), Toluene (C3), Benzoic acid (C4), Acetophenone (C5), Chlorobenzene (C6), Bromobenzene (C7), Benzaldehyde (C8), Naphthalene (C9), and Anthracene (C10) were investigated using quantum mechanical methods. energy the highest occupied molecular orbital (EHOMO), lowest (ELUMO), bandgap (E = ELUMO - EHOMO), dipole moment (μ)...

This experimental study investigates the possible protective effects of Gum Arabic (GA) and its nanoparticles in hepato- reno-toxicity induced by bromobenzene (BB) rats mechanisms action. Thirty-five adult male albino were sorted into following: Group 1 (control), 2 (NPs), 3 (GA, received ml/kg 10%w/v aqueous suspension), 4 (Gum-NPs, GA loaded NPs), 5 (BB), 460 mg/kg, 6 (GA+BB) 7 (GA-NPs+BB). T...

Allium Jesdianum (AJ) is the native plant mostly grown in Middle East region that has the excellent pharmacological properties. In this study, we evaluated the hepatoprotective effect of hydroalcoholic extract of AJ on liver injury induced by Bromobenzene (BB) in male mice. Animals were randomly divided into five groups, control group received normal saline plus olive oil, groups 2-4 received(5...

Background & objectives: The present investigation was designed to evaluate the post-treatment properties of the hydroalcoholic fruit extract of cassia fistula (golden shower tree) in male Albino mice. Materials & Methods: Biomarkers and histological liver and kidney alterations, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (...