The lack of standardisation of breath sampling is a major contributing factor to the poor repeatability of results and hence represents a barrier to the adoption of breath tests in clinical practice. On-line and bag breath sampling have advantages but do not suit multicentre clinical studies whereas storage and robust transport are essential for the conduct of wide-scale studies. Several device...

Exhaled breath is a body secretion, and the sampling process of this is simple and cost effective. It can be non-invasively collected for diagnostic procedures. Variations in the chemical composition of exhaled breath resulting from gaseous exchange in the extensive capillary network of the body are proposed to be associated with pathophysiological changes. In light of the foreseeable potential...

Rationale Malignant pleural mesothelioma (MPM) is mainly caused by previous exposure to asbestos fibers and has a poor prognosis. Due to a long latency period between exposure and diagnosis, MPM incidence is expected to peak between 2020-2025. Screening of asbestos-exposed individuals is believed to improve early detection and hence, MPM management. Recent developments focus on breath analysis ...

This paper, based on a selected one hour of expressive speech, is a pilot study on how to use breath segments to get more natural and expressive speech. It mainly deals with the status of when the breath segments occur and how the acoustic features are affected by the speaker ’s emotional states in terms of valence and activation. Statistical analysis is made to investigate the relationship bet...

The potential of breath analysis for clinical diagnosis and the strengths and weaknesses of the analytical methods used are discussed. Special attention is given to selected ion flow tube mass spectrometry, SIFT-MS, using which on-line real-time analyses of single breath exhalations can be carried out. Illustrative data on the concentration distributions of several breath metabolites amongst th...

REMPI (Resonantly Enhanced Multi Photon Ionization) is an ultra-sensitive analytical technique based on the unique combination of laser spectroscopy and mass spectrometry that can rapidly identify and quantify vapor-phase constituents present at part per trillion levels. We have used this method to examine human breath samples for biomarkers of infection. Based on the observed results, we estim...

Introduction: Residual patient motion between images in breath-hold DCE-MRI may compromise image analysis such as the extraction of pharmacokinetic parameters. This work analyses results of the Progressive Principal Component Registration (PPCR) algorithm [1] on six 3D DCE-MRI datasets. These datasets are acquired at a temporal resolution of 12s consisting of a 6s breath-hold volume acquisition...

Monitoring blood glucose concentrations is a necessary but tedious task for people suffering from diabetes. It has been noted that breath in people suffering with diabetes has a different odour and thus it may be possible to use breath analysis to monitor blood glucose concentration. Here, we evaluate the analysis of breath using a portable device containing a single mixed metal oxide sensor du...

18 This “Perspective” reflects our observations of recent accomplishments made using SIFT19 MS. Only brief descriptions are given of SIFT-MS as an analytical method and of the recent 20 extensions to the underpinning analytical ion chemistry required to realise more robust 21 analyses. The challenge of breath analysis is given special attention because, when achieved, 22 it renders analysis of ...

OBJECTIVE To determine the association of spirometric lung pattern with respiratory symptoms and to validate the American Thoracic Society respiratory questionnaire for lung function assessment among textile workers. METHODS This cross-sectional survey was conducted from August to December 2009 among adult textile workers of Karachi. Data was collected through the American Thoracic Society Di...