Tissue phytosterol and cholesterol levels in 10 benign and 8 malignant breast tumors were quantitated to reexamine the hypothesis that malignant tumors had distinctive phytosterol content. Phytosterols were present in 9 of 10 benign and 7 of 8 malignant breast tumors. Mean (+/- S.E.) cholesterol, campesterol, stigmasterol, and beta-sitosterol in malignant and benign tumors (microgram/g wet weig...

Introduction: The gastrin releasing peptide (GRP) receptor is over expressed in a variety of common human tumors. Radiolabeled bombesin analogues have exhibited high binding affinity for these receptors. The aim of this study was to assess the value of a new 99mTc-bombesin analog in the differentiation of malignant from benign breast tumors. Methods: 99mTc-bombesin scans ...

OBJECTIVE: To evaluate ipsilateral breast tumor recurrence after breast-conserving surgery for locally advanced breast cancer. METHODS: A retrospective observational cohort study was performed in patients with locally advanced breast cancer submitted to breast-conserving surgery after neoadjuvant chemotherapy based on an adriamycin-cyclophosphamide-paclitaxel regimen. We evaluated the clinica...

The WHO categorizes the breast tumors in various distinct histological types based on cell morphology and architecture. A widely accepted fact that aggressive nature of cancer can be determined by its type, grade, nodal status, metastasis holds ground even era immunohistochemistry (IHC) molecular. An extremely rare variant primary carcinoma belongs to family mucin producing sharing same histolo...

The breast cancer susceptibility gene 1 (BRCA1) and glutathione S-transferase P1 (GSTP1) promoters are reportedly often methylated in breast cancer tissues. Their methylation status in surrounding normal breast tissues has not been examined thoroughly although this may well be important for a better understanding of breast carcinogenesis. In this study, BRCA1 and GSTP1 promoter methylation was ...

Background&Aims:True local recurrences(TR)and new primary tumors(NP)in the conserved breast after breast-conserving surgery with radiation therapy are determined by the initial surgical margin,the location of recurrent tumors and the histological consistency between initial tumors and recurrent tumors. Methods:A total of 15 patients with breast recurrence out of a group of 389 women with breast...

Background: Aberrant methylation of cytosine-guanine dinucleotide islands leads to inactivation of tumor suppressor genes in breast cancer. Tumor suppressor genes are unmethylated in normal tissue and often become hypermethylated during tumor formation, leading to gene silencing. We investigated the association between E-cadherin (CDH1) and estrogen receptor-α (ESRα) gene promoter methylation a...

BACKGROUND The possible role of viruses in breast cancer etiology remains an unresolved question. We hypothesized that if some viruses are involved, it may be in a subgroup of breast cancers only. Epidemiological arguments drove our interest in breast cancer subgroups that are more frequent in Africa, namely inflammatory breast cancer (IBC) and triple-negative breast cancer. We tested whether v...

Cystic breast mass is one of the common conditions seen presented in any breast clinic. Evaluating such cystic breast lesions is very important. Malignant cystic tumors like mucinous carcinomas and papillary carcinomas have to be differentiated from common benign cystic lesions of the breast like fibrocystic lesions and papillomas. Malignant breast cancers that present as cystic lesions are see...

Objective: Breast lesions in childhood are mostly benign and self-limiting, the biopsy indications restricted this period. The differentiation between fibroadenomas phyllodes tumors is difficult with imaging because of their overlap initial size growth rate. Therefore, or excision may be required. Material Methods: We retrospectively reviewed data from 531 patients (404 females, 76.1%; 127 male...