Breast cancer is the most common neoplasm affecting women in the western world with an average frequency of 1 in 11, developing the malignancy and it is second most common cancer in India. Variations in serum levels of biochemical parameters especially alkaline phosphatase (ALP) changes may be of great help in diagnosis of breast carcinoma. Serum ALP activity was assayed in 388 histopathologica...

Granular cell tumors (granular cell rnyoblastoma) are neoplasms Which pursue a benign clinical course in large majority of cases. Tongue is the classic location for this tumor, however, rarely it is seen ill many other sites. Cases of granular cell tumor have been described in both male and female breasts The recognition of this entity in breast is important because it mimics breast carcinoma c...

Different types of non-invasive epithelial mammary lesions are associated to a risk of developing breast cancer in the human and canine species. The process of malignant neoplasm progression is observed in canine mammary tumors, where the development of carcinomatous foci (carcinomas in situ) may result in the formation of invasive carcinomas associated to these tumors (Bertagnolli et al., 2009...

MRI provides a highly sensitive technique for early detection of abnormal breast tissue. It is useful for identifying a status of proliferation, angiogenesis, and microvascular permeability, which may indicate early breast neoplasm formation. We retrospectively studied 2005 breast MRI images from Taiwanese women and classified them as either healthy or unhealthy according to BI-RADS categories....

The human serum Sex Hormone-Binding Globulin (SHBG) plays an important role in breast cancer pathophysiology and risk definition, since it regulates the bioavailable fraction of circulating estradiol. We here summarize data reported over the years concerning the involvement of SHBG and SHBG polymorphisms in the definition of breast cancer risk. We also report what is known about the direct acti...

Breast cancer is a very heterogeneous neoplasm characterized by various molecular and clinical peculiarity. There has been several studies about ALDH1 cells which has the ability to form breast tumors. However, there is still controversy about these findings. However, as there are still controversies, verification of these findings are needed. Recently, the author evaluated the relationship bet...

Male breast carcinoma is a rare neoplasm, accounting for fewer than 1% of all malignancies of the breast. We report the case of a 65-year-old man who presented at our institution with a lump in his left breast. Histologically, the tumour had marked nuclear pleomorphism and contained multinucleated giant cells. Immunohistochemical staining demonstrated that the tumour cells were positive for cyt...

Breast cancer is the most prevalent neoplasm and second leading cause of death among females in Kenya. Estrogen its metabolites are known risk factors for breast cancer. Polymorphisms these genes susceptibility unique different populations. This study aimed to determine probable associations between estrogen-metabolizing gene variations other Kenyan women. Buffy coat samples were obtained from ...

BACKGROUND: Maspin (a tumor suppressor gene) is down-regulated in breast, prostate, gastric, and melanoma. Although it not detected normal pancreatic tissue, over-expressed cancer suggesting that maspin may play different activities cell types. Pancreatic ductal adenocarcinoma (PC) acquires expression through hypomethylation of its promoter. AIM: Because the discrimination between ampullary per...

Mucosa associated lymphoid tissue (MALT) lymphoma is a lymphoid neoplasm arising in extranodal sites with histologic features similar to those of nodal marginal zone lymphoma. Among the sites where a primary MALT lymphoma arises, the GI tract is the most common whereas the breast represents only 4%. Bilateral involvement of the breasts by a primary MALT lymphoma is exceptional with only 10 case...