In the present study, various 28 hybrid molecules containing hydrazone and sulfonate moieties were synthesized characterized by FTIR, 1H-NMR, 13C-NMR spectroscopy LC-MS spectrometry, besides elemental analysis. The compounds evaluated for their antiproliferative effects against six cancer cell lines, namely A549 (non-small lung cancer), MCF-7 (breast HT-29 (colorectal adenocarcinoma PC-3 (andro...

Metastases to the skin from internal tumors are uncommon, yet they may be the first presentation of such malignancies. They usually arise from the breast, lung and large bowel. Cutaneous metastases from gastric adenocarcinoma are extremely rare. We report a case of gastric adenocarcinoma that at presentation had multiple clinically benign looking skin nodules. Fine needle aspira...

A series of fluorinated tetrahydropyrano[3,2-c]chromenes and dihydropyrano[3,2-b]pyran derivatives have been synthesized and their in vitro cytotoxic activities have been determined in cervical cancer cell line (HeLa), human breast adenocarcinoma cell line (MDA-MB-231 and MCF-7) and human alveolar adenocarcinoma cell line (A549). Compounds 4g, 4k, 4p showed a very potent activity against MDA-MB...

Mixed ligand nickel (II), complexes of 2, 2 bipridyle and thioamides 2-aminopyridine, 2-aminoadinine, 2-aminoguanine 2-aminocytocine were prepared. The success synthesis was confirmed through physical spectral characterization on the basis IR NMR spectroscopy, antimicrobial antitumour studies. synthesized compounds found to be active against tested three bacterial strains (Pseudomanas auruginos...

Bio-inspired techniques are used for synthesis in terms of application, green chemical research, facile, and eco-friendly chemistry study silver nanostructures utilizing plant extracts as natural reducing/stabilization solid adjuvants without the use toxic damaging reagents. The present investigates biosynthesis Ag nanoparticles via mediation methanolic extract Heracleum persicum seeds, any sta...

Breast metastasis from extra-mammary malignancy is rare. Based on the literature an incidence of 0.4-1.3% is reported. The primary malignancies most commonly metastasizing to the breast are leukemia-lymphoma, and malignant melanoma. We present a case of metastasis to the breast from a pulmonary adenocarcinoma, with extensive micropapillary component, diagnosed concomitantly with the primary tum...

Recently, mutations of the transforming growth factor-b receptor type I gene have been reported to occur at high frequency in breast cancer metastases, with all mutations being an identical C to A transversion at nucleotide 1160 of the gene (T. Chen et al., Cancer Res., 58: 4805–4810, 1998). This mutation would result in a serine to tyrosine substitution at codon 387 (S387Y) and would reportedl...

Recently, mutations of the transforming growth factor-beta receptor type I gene have been reported to occur at high frequency in breast cancer metastases, with all mutations being an identical C to A transversion at nucleotide 1160 of the gene (T. Chen et al, Cancer Res., 58: 4805-4810, 1998). This mutation would result in a serine to tyrosine substitution at codon 387 (S387Y) and would reporte...

There are very few cases reported of adenocarcinoma of the tongue. We report an unusual case of a 60-year-old female having a large, pedunculated ductal adenocarcinoma that had arisen from ventral surface of the tongue. The lesion was managed by surgery.

In the articles “The malignant transformation of retrorectal cystic hamartomas with blood irregular antibodies positive: A case report” and “Urachal adenocarcinoma that metastasized to breast was misinterpreted as primary breast mucinous carcinoma: A rare case report and literature review”, which appeared in Volume 94, Issue 49 and Volume 95, Issue 35, respectively, of Medicine, a university af...