background: volume estimation of brain is important for many neurological applications. it is necessary in measuring brain growth and changes in brain in normal/abnormal patients. thus, accurate brain volume measurement is very important. magnetic resonance imaging (mri) is the method of choice for volume quantification due to excellent levels of image resolution and between-tissue contrast. st...

Intraindividual variability (IIV) refers to reaction time (RT) variation across the trials of a given cognitive task. Little research has contrasted different measures of IIV or assessed how many RT trials are required to provide a robust measure of the construct. We, therefore, investigated three measures of IIV (raw SD, coefficient of variation, and intraindividual SD statistically removing t...

With interest we have read the article by White et al. 1 In their well-designed prospective cohort study, they demonstrate the importance of increased 24-hour systolic blood pressure, but not clinic systolic blood pressure, in the progression of brain white matter hyperintensity volume burden associated with impairment of cogni-tive function in older people. They conclude that 24-hour of systol...

In molecular terms, the blood–brain barrier (BBB) indicates tight junction complexes between adjacent endothelial cells that, combined with endothelial transporters (both influx and efflux), make brain endothelia different from other endothelia. While highly advantageous as a protective barrier against cerebrovascular permeability, shielding sensitive brain elements from blood-borne agents, it ...

Subacute sclerosing panencephalitis (SSPE) is a progressive, fatal neurological disorder of childhood and early adolescence. In this report, we present brain magnetic resonance spectroscopy (MRS) and conventional magnetic resonance MR imaging findings of early-stage (stage II) SSPE in an 8-year-old child. MRS demonstrated increased myo-inositol/creatine and choline/creatine ratios, and a decrea...

BACKGROUND AND PURPOSE MRI-based quantification of gray and white matter volume is common in studies involving elderly patient populations. The aim of the present study was to describe the effects of not accounting for subcortical white matter hyperintensities (WMH) on tissue volumes in Alzheimer Disease patients with varying degrees of WMH (mild: n=19, moderate: n=22, severe: n=18). METHODS ...

BACKGROUND Heart failure (HF) patients are at risk for structural brain changes due to cerebral hypoperfusion. Past work shows obesity is linked with reduced cerebral blood flow and associated with brain atrophy in healthy individuals, although its effects on the brain in HF are unclear. This study examined the association among body mass index (BMI), cerebral perfusion, and brain volume in HF ...

A fundamental controversy is whether cognitive decline with advancing age can be entirely explained by decreased processing speed, or whether specific neural changes can elicit cognitive decline, independent of slowing. These hypotheses are anchored by studies of healthy older individuals where age is presumed the sole influence. Unfortunately, advancing age is also associated with asymptomatic...

BACKGROUND Single-nucleotide polymorphisms (SNPs) in 2 distinct regions of the gene for the sortilin-related receptor (SORL1) (bounded by consecutively numbered SNPs 8-10 and 22-25) were shown to be associated with Alzheimer disease (AD) in multiple ethnically diverse samples. OBJECTIVE To test the hypothesis that SORL1 is associated with brain magnetic resonance imaging (MRI) measurements of...

BACKGROUND White-matter hyperintensities have been associated with both schizophrenia and mood disorders, particularly bipolar disorder, but results are inconsistent across studies. AIMS To examine whether white-matter hyperintensities are a vulnerability marker for psychosis or are specifically associated with bipolar disorder. METHOD T(2)-weighted magnetic resonance imaging data were acqu...