Abstract Lung cancer is the most common to metastasize brain, with 50% of all brain metastases originating from lung primary tumors. Traditional therapy for includes surgical resection, radiation, and chemotherapy. Due presence blood-tumor barrier, penetration therapeutics significantly hindered. Even when used in combination, tumor recurrence regrowth after initial chemoradiotherapy remain a s...

Wound bacterial infections and tumor recurrence are the main reasons for poor prognosis after primary resection. Here, we fabricated a novel therapeutic nanocomposite using chitosan (CS) hydrogel combined with black phosphate nanosheets (BPNSs) in situ grown copper nanoparticles (CuNPs). The obtained ([email protected]@CuNPs), possessing remarkable temperature-sensitive spongy-like state, offer...

Abstract OBJECTIVE The role of surgery in recurrent GBM remains a controversial topic. goal this study was to perform case-control analysis including time tumor recurrence as an additional prognostic factor order determine which patients benefit most from repeat surgery. METHODS Our brain database reviewed over ten-year period for all adult (≥ 18 years old) with primary IDH wildtype that receiv...

OBJECTIVE Recurrence of glioblastoma multiforme (GBM) arises from areas of microscopic tumor infiltration that have yet to disrupt the blood-brain barrier. We hypothesize that these microscopic foci of invasion cause subtle variations in the apparent diffusion coefficient (ADC) and FLAIR signal detectable with the use of computational big-data modeling. MATERIALS AND METHODS Twenty-six patien...

purpose: this study was conducted to assess cognitive impairments, depression, anxiety and quality of life among patients with brain tumor and healthy adults, comparatively. methods: a cross-sectional study was administrated on 84 brain tumor patients and 84 healthy adults measured by the mini mental state examination, beck, hamilton and sf36 questionnaires before and after 10 days of surgery. ...

Background: To determine which radiotherapy parameters are associated with the tumor response of locally advanced non-small cell lung cancer (NSCLC) patients undergoing concurrent chemoradiotherapy. Materials and Methods: Thirty one patients with IIIA/IIIB NSCLC underwent chemoradiotherapy with a median dose of 63 Gy. On our actual treatments, we made radiotherapy planning to cover the planning...

Objective Total resection without consecutive postoperative whole brain radiation therapy is indicated for patients with a single or two sites of brain metastasis, with close follow-up by serial magnetic resonance imaging (MRI). In this study, we explored the effectiveness, usefulness, and safety of this follow-up regimen. Methods From January 2006 to December 2015, a total of 109 patients (7...

Abstract Glioblastoma (GBM) is the most common and aggressive primary brain tumor. The only intervention that has improved survival rate of GBM patients over past several decades been combining temozolomide (TMZ) with radiotherapy (RT), which increased median by ~2.5 months to where it currently stands at ~15 months. Unfortunately, all eventually die due tumor recurrence. Intrinsic or acquired ...

OBJECTIVE The aim of the paper was to investigate the recurrence and its causes of radiation brain necrosis following bevacizumab discontinuation. METHODS This study included 14 patients with radiation brain necrosis (confirmed through imaging) after stereotactic radiotherapy for a primary or metastatic brain tumor and who received bevacizumab treatment from June 2011 through December 2014. T...

BACKGROUND Meningiomas show high recurrence rates even after curative tumor removal. The invasiveness of meningiomas may contribute to their high recurrence rates. Recently, c-MET and hepatocyte growth factor (HGF) have been reported to be involved in cancer invasion. METHODS We examined the immunohistochemical expression of c-MET and HGF in 100 cases of patients with meningiomas who have und...