aim: oxidative stress plays a crucial role in the pathophysiology of ischemic stroke. since water-solublefullerene derivatives act as the potent scavenger of oxygen free radicals in biological systems, we aimedto investigate the possible protective effects of fullerol nanoparticles on brain infarction and edema intransient model of focal cerebral ischemia in rat.materials & methods: experiment ...

freckles and pigmented acne scars, are of serious concern to women. Their treatment usually involves the use of medicines or medicinal cosmetics containing depigmenting agents or skin-whitening agents. For example, hydroquinone and 4methoxyphenol are used as topical therapies for hyperpigmentation disorders. Active ingredients available for medicated whitening cosmetics in Japan include vitamin...

Eicosapentaenoic acid prevents platelet aggregation and inhibits arachidonate conversion into thromboxane A2 and prostaglandins. Consequently eicosapentaenoic acid might protect the brain from the ischemia that follows cerebral arterial occlusion. We studied the effect of eicosapentaenoic acid on cerebral ischemia in anesthetized gerbils. Ischemia was produced by bilateral carotid occlusion for...

Introduction: Cytokines production as one of the inflammatory pathways in CNS is responsible for most brain damages following ischemia. On the other hand, during inflammation and brain ischemia, most of the renin- angiotensin components (RAS) increase locally. While it is established that blockade of RAS especially AT1 receptors has a protective effect on ischemia, the interaction of cytokines ...

The relevance and importance of treating patients with ischemic brain lesions are indisputable. Chronic processes in the occur much more frequently than acute cerebral circulation disorders, leading to prolonged disability being main contributors a significant number strokes. Cognitive dysfunctions prevail dynamics post-ischemic period often primary determinants severity residual organic subseq...

pervious studies have shown that pentoxifylline (ptx) has beneficial effects in reduction of stroke and brain trauma injuries in experimental animals. however, there is very little and controversial information about the effect of ptx on brain edema in cerebral ischemia. therefore, the aim of this study was to determine the effects of different doses of ptx on brain edema and neurological motor...

introduction: neuroinflammation may play as an important risk factor in progressive degeneration of dopaminergic cells. antioxidants have protective effects against free radicalsinduced neural damage in parkinson’s disease (pd). in the present study, we examined the effects of ellagic acid (ea) on locomotion and neuroinflammatory biomarkers in a rat model of pd induced by 6-hydroxidopamine (6-o...

introduction: the purpose of this study was to determine na-ca exchanger 2, 3 (ncx2, 3) protein level changes during 2, 5, 10, 15 days after induction of normobaric hyperoxia (ho) preconditioning. materials and methods: rats were divided in two experimental groups. the first group was exposed to 95% inspired ho for 4 h/day for 6 consecutive days (ho). the second group acted as control, and was ...

traumatic brain injury (tbi) is one of the serious neurodisorders commonly caused by car accidents and sports. preventive measures are highly recommended to reduce the risk and number of tbi cases. after tbi, the primary injury to the brain initiates a secondary injury process that spreads via multiple molecular mechanisms in the pathogenesis of tbi. many studies in animals using cdna microarra...