Traumatic brain injury (TBI) is one of the main causes of mortality and severe disability in young and middle age patients. Patients with severe TBI, who are in coma, are of particular concern. Adequate diagnosis of primary brain injuries and timely prevention and treatment of secondary injury mechanisms markedly affect the possibility of reducing mortality and severe disability. The present gu...

ObjectiveThe aim of this manuscript is to compare characteristics, management, and outcomes patients with severe Traumatic Brain Injury (TBI) between Australia, the United Kingdom (UK) Europe.MethodsWe enrolled TBI in Victoria, Australia (OzENTER-TBI), UK Europe (CENTER-TBI) from 2015 2017. Main outcome measures were mortality unfavourable (Glasgow Outcome Scale Extended <5) 6 months after inju...

Tau is a protein that has received national mainstream recognition for its potential negative impact to the brain. This review succinctly provides information on structure of tau and normal physiological functions, including in hibernation changes throughout estrus cycle. There are many pathways involved phosphorylating diabetes, stroke, Alzheimer’s disease (AD), brain injury, aging, drug use. ...

OBJECTIVE The long-term effects of traumatic brain injury (TBI) can resemble observed in normal ageing, suggesting that TBI may accelerate the ageing process. We investigate this using a neuroimaging model that predicts brain age in healthy individuals and then apply it to TBI patients. We define individuals' differences in chronological and predicted structural "brain age," and test whether TB...

Traumatic brain injury (TBI) is a complex injury involving several physiological alterations, potentially leading to neurological impairment. Previous mouse studies using high-density oligonucleotide array analysis have confirmed the upregulation of transforming growth-interacting factor (TGIF) mRNA in TBI. TGIF is a transcriptional corepressor of transforming growth factor beta (TGF-β) signali...

This study evaluated the utility of combinational therapy, coupling delayed posttraumatic hypothermia with delayed FK506 administration, on altered cerebral vascular reactivity, axonal injury, and blood-brain barrier (BBB) disruption seen following traumatic brain injury (TBI). Animals were injured, subjected to various combinations of hypothermic/FK506 intervention, and equipped with cranial w...

Traumatic brain injury (TBI) is one of the major causes of disability in modern society. The World Health Organization has predicted that, by 2020, traffic accidents will represent the greatest burden of global disease and injury. Brain injury after trauma occurs in two stages. Primary injury is directly associated with the biomechanical effects of the trauma, whereas secondary injury occurs la...

Traumatic brain injury (TBI) is a public health problem worldwide. Secondary damage of brain injury begins within a few minutes after the trauma and can last a long time. It can be reversible, unlike primary injury. Therefore, therapeutic intervention can be used. The aims of this study were to assess the effects of minocycline on neurological function and serum S100B protein and neuron-specifi...

background traumatic brain injury (tbi) is an important public health problem throughout the world. objective this study assesses repeated glasgow coma scale (gcs) scores to predict the severity of tbi and survival of the patients. materials and methods a sample of 239 patients who were hospitalized with traumatic brain injury was selected by random sampling from icu wards at shahid beheshti ho...

Traumatic brain injury (TBI) is a public health problem worldwide. Secondary damage of brain injury begins within a few minutes after the trauma and can last a long time. It can be reversible, unlike primary injury. Therefore, therapeutic intervention can be used. The aims of this study were to assess the effects of minocycline on neurological function and serum S100B protein and neuron-specifi...