Progressive compromise of antioxidant defenses and free radical-mediated lipid peroxidation, which is one of the major mechanisms of secondary traumatic brain injury (TBI), has also been reported in pediatric head trauma. In the present study, we aimed to demonstrate the effect of melatonin, which is a potent free radical scavenger, on brain oxidative damage in 7-day-old rat pups subjected to c...

Clobazam, one of the newer benzodiazepines, is now used extensively as first add on therapy in focal epilepsy. A 67-year-old diabetic and hypertensive gentleman with a history frontal contusion year ago, presented clustering seizures. He was started clobazam 20 mg, levetiracetam 1000 mg/day. Recurrence seizures prompted dose escalation to 40 The patient developed hepatic encephalopathy his deco...

Pulmonary contusion is the most common thoracic soft tissue injury encountered in motor vehicle crashes and is seen in 10-17% of all trauma admissions. This study presents a biomechanical and radiological analysis with the goal of quantifying pulmonary contusion resulting from motor vehicle crashes in order to illustrate the relationships between crash characteristics, contusion severity, and p...

motor vehicle and falling down are responsible for the most number of traumatic injuries. this study aimed to compare the characteristics of traumatic brain injury among accident and falling down cases. in this analytical cross- sectional study, data were collected from the records of cadavers who died due to accident or falling down and referred to kahrizak dissection hall, tehran forensic med...

Background & Aim: Post-traumatic subdural hygroma can be associated with subdural or epidural hematoma. It is usually silent with mild symptoms and often disappears spontaneously needing no treatment. In this study, we investigated the clinical characteristics of subdural hygroma in patients with traumatic brain injury. Methods & Materials/Patients: In a cross-sectional study, data o...

lung contusion is an entity involving injury to the alveolar capillaries, without any tear or cut in the lung tissue. this results in accumulation of blood and other fluids within the lung tissue. the excess fluid interferes with gas exchange leading to hypoxia. the pathophysiology of lung contusion includes ventilation/perfusion mismatching, increased intrapulmonary shunting, increased lung wa...

INTRODUCTION The triggering receptor expressed on myeloid cells-1 (TREM-1) is known to be expressed during bacterial infections. We investigated whether TREM-1 is also expressed in non-infectious inflammation following traumatic lung contusion. METHODS In a study population of 45 adult patients with multiple trauma and lung contusion, we obtained bronchoalveolar lavage (BAL) (blind suctioning...