introduction: photon attenuation in tissues is the primary physical degrading factor limiting both visual qualitative interpretation and quantitative analysis capabilities of reconstructed single photon emission computed tomography (spect) images. the aim of present study was to investigate the effect of attenuation correction on the detection of activation foci following statistical analysis w...

Ultrapotent chemogenetics, including the chloride-permeable inhibitory PSAM 4 -GlyR receptor, were recently proposed as a powerful strategy to selectively control neuronal activity in awake, behaving animals. We aimed validate function of dopamine D1 receptor-expressing medium spiny neurons (D1-MSNs) ventral striatum. Activation with uPSEM 792 ligand enhanced rather than suppressed D1-MSNs vivo...

introduction: repetitive cortical spreading depression (csd) can lead to cell death in immature brain tissue. caspases are involved in neuronal cell death in several csd-related neurological disorders. yet, whether repetitive csd itself can induce caspase activation in adult or juvenile tissue remains unknown. inducing repetitive csd in somatosensory cortices of juvenile and adult rats in vivo,...

P2x7 receptors are Purineric receptors that are extracellular ATP-gated ion channel. These receptors require high dose or prolonged exposure to ATP for initial activation. The Activation of these receptors facilitates the formation of inflammasome which activates caspase 1. The P20 and P10 subunits of caspase 1 form active enzyme that then releases active interleukin (IL)-1 β and IL-18, tu...

Abstract Can the brain be shifted into a different state using simple social cue, as tests on highly hypnotizable subjects would suggest? Demonstrating an altered global is difficult. Brain activation varies greatly during wakefulness and can voluntarily influenced. We measured complexity of electrophysiological response to transcranial magnetic stimulation in one ‘hypnotic virtuoso’. Such meas...

Significance Slow waves are the predominant feature of brain activity during sleep and anesthesia. associated with plasticity, memory consolidation, other functions. However, much remains unknown about circuits that coordinate slow wave propagation. Here, we demonstrate somatosensory stimulation evokes bilateral activation primary cortices (S1). Under anesthesia, S1 is followed by a global, fro...

traumatic brain injury (tbi) is physical damage to the brain structure which has a high global rate of mortality and morbidity. tbi can cause intense inflammatory response due to accumulation of leukocytes in cerebral matrix and activation of microglia. microglia can differentiate into m1 macrophages or m2 macrophages following the changes in biochemical properties of brain tissue. m1 sub type ...