TDP-43 is a multifunctional DNA/RNA-binding factor that has been implicated in the regulation of neuronal plasticity. TDP-43 has also been identified as the major constituent of the neuronal cytoplasmic inclusions (NCIs) that are characteristic of a range of neurodegenerative diseases, including the frontotemporal lobar degeneration with ubiquitin(+) inclusions (FTLD-U) and amyotrophic lateral ...

BACKGROUND Interstitial rotating shield brachytherapy (I-RSBT) is a recently developed method for treatment of prostate cancer. In the present study TG-43 dosimetric parameters of a 153Gd source were obtained for use in I-RSBT. MATERIALS AND METHODS A 153Gd source located inside a needle including a Pt shield and an aluminum window was simulated using MCNPX Monte Carlo code. Dosimetric parame...

introduction dosimetric accuracy is a major issue in the quality assurance (qa) program for treatment planning systems (tps). an important contribution to this process has been a proper dosimetry method to guarantee the accuracy of delivered dose to the tumor. in brachytherapy (bt) of gynecological (gyn) cancer it is usual to insert a combination of tandem and ovoid applicators with a complicat...

Background: The dose rate distribution delivered by a low dose rate 137Cs pellet source, a spherical source used within the source trains of the Selectron gynecological brachytherapy system, was investigated using the MCNP4C Monte Carlo code. Materials and Methods: The calculations were performed in both water and Plexiglas and the absolute dose rate distribution for a single pellet s...

www.onk.ns.ac.rs/Archive Vol 20, No. 1–2, July 2012 INTRODUCTION The GZP6 high dose rate (HDR) afterloading brachytherapy unit (Nuclear Power Institute of China) (1) has recently been introduced in the Iranian radiation oncology centers. The unit has six different cobalt-60 source braids being loaded in tandem and ovoid applicators. The sources are used in the treatment of cervix, vagina, rectu...

BACKGROUND Keloids as unusual scars are injury remnants characterized by bizarre cosmetics and painful itching. This study assessed outcomes of surgical excision and brachytherapy in intractable keloids. METHODS Six patients with 10 keloid lesions were followed up. Surgical excision was done with 1-2 mm margin, and then radiotherapy was undertaken in 3 divided fractions on days 0, 1 and 2 ...

Introduction Dosimetric accuracy is a major issue in the quality assurance (QA) program for treatment planning systems (TPS). An important contribution to this process has been a proper dosimetry method to guarantee the accuracy of delivered dose to the tumor. In brachytherapy (BT) of gynecological (Gyn) cancer it is usual to insert a combination of tandem and ovoid applicators with a complicat...

Purpose Brachytherapy (BT) deals with high gradient internal dose irradiation made up of a complex system where the source is placed nearby tumor to destroy cancerous cells. A primary concern clinical safety in BT quality assurance ensure best matches between delivered and prescribed doses targeting small volume tumors sparing surrounding healthy tissues. Hence, purpose this study evaluate perf...

PURPOSE To determine outcomes of interstitial high-dose-rate brachytherapy (HDR-BT) in patients with early stage oral tongue cancer. MATERIAL AND METHODS Ninety-two patients with stage I and II oral tongue cancer were treated with HDR-BT between 1999 and 2014: brachytherapy alone = 62 (67.4%), and combination of external beam radiotherapy (EBRT) and brachytherapy = 30 (32.6%). Median follow-u...

Purpose: A simple method for verifying the dose point kernel of Ir-192 source used in HDR brachytherapy using Kodak EDR2 film in a spiralphantom. Method and Materials: A spiral solid water phantom availablefrom Gammex International for IMRT QA was modified for this study. A CT scan image of the phantom was acquired with a 10 x 12 inch filmloaded in the spiral groove. A 3.5 mm long 8...