Bone tissue engineering is a promising field of regenerative medicine in which cultured cells, scaffolds, and osteogenic inductive signals are used to regenerate bone. Human bone marrow stromal cells (BMSCs) are the most commonly used cell source for bone tissue engineering. Although it is known that cell culture and induction protocols significantly affect the in vivo bone forming ability of B...

A review about design, manufacture, and mechanobiology of biodegradable scaffolds for bone tissue engineering is given. First, fundamental aspects about bone tissue engineering and considerations related to scaffold design are established. Second, issues related to scaffold biomaterials and manufacturing processes are discussed. Finally, mechanobiology of bone tissue and computational models de...

Objective(s): Tissue engineering aims to achieve a tissue, which has highly interconnected porous microstructure concurrent with appropriate mechanical and biological properties. Materials and Methods: Therefore, the microstructure scaffolds are of great importance in this field. In the present study, an electroconductive poly-lactic acid (EC-PLA) filament used to fabricate a porous bone ...

Background: Monolayer electrospun scaffolds have already been used in bone tissue engineering due to their high surface-to-volume ratio, interconnectivity, similarity to natural bone extracellular matrix (ECM), and simple production. Objectives: The aim of this study was to evaluate the dynamic culture effect on osteogenic differentiation and mineralizationi into a compact cellular multilayer ...

Human bone is susceptible to damage from infections, fractures, and diseases. They do, however, have an amazing ability repair themselves after being exposed such factors, which accomplished by a dynamic process of remodeling, maturation, differentiation, regulated resorption. Larger defects, on the other hand, cannot be fully restored because their sizes exceed capacity bones repair. In cases,...

Nano-Hydroxyapatite (nHAP) is a very valuable mineral that is widely used in tissueengineering as well as bone and dental repair. Moreover, it is a major component of bone, enamel and dentin that can interact effectively with healing tissues due to its high biocompatibility. It is important to note that the purpose of its medical application can be identified based on the structure and sy...

The worldwide incidence of bone disorders and conditions has trended steeply upward and is expected to double by 2020, especially in populations where aging is coupled with increased obesity and poor physical activity. Engineered bone tissue has been viewed as a potential alternative to the conventional use of bone grafts, due to their limitless supply and no disease transmission. However, bone...

Tissue engineering evolved from the field of biomaterials development and refers to combining scaffolds, cells, and biologically active molecules into functional tissues. Tissue engineering is defined as a multidisciplinary scientific branch that combines cell biology, materials science and engineering, and regenerative medicine [1]. The goal of tissue engineering is to assemble such fully func...