Under normal conditions, loading activities result in microdamage in the living skeleton, which is repaired by bone remodeling. However, microdamage accumulation can affect the mechanical properties of bone and increase the risk of fracture. This study aimed to determine the effect of microdamage on the mechanical properties and composition of bone. Fourteen male goats aged 28 months were used ...

While mammals have a limited capacity to repair bone fractures, zebrafish can completely regenerate amputated bony fin rays. Fin regeneration in teleosts has been studied after partial amputation of the caudal fin, which is not ideal to model human bone fractures because it involves substantial tissue removal, rather than local tissue injury. In this work, we have established a bone crush injur...

Current surgical treatments and material applications are not ideal for the treatment of orthopedic clinical injuries, such as large bone defects, cartilage vascular tendon adhesions that occur after repair. With continuous development tissue engineering technology, hydrogels have become important medical biomaterials. Hydrogels three-dimensional hydrophilic network structures composed cross-li...

The ideal biomaterials substitute for bone repair should possess the following characteristics: provide osteogenic, osteoinductive and osteoconductive properties; stimulate neo-angiogenesis process; absence of antigenic, teratogenic or carcinogenic reactions; avoid systemic toxicity complications; assure satisfactory support stability from mechanical properties point view; hydrophilic nature su...

BACKGROUND In this study we evaluated a novel approach to guide the bone marrow-driven articular cartilage repair response in skeletally aged rabbits. We hypothesized that dispersed chitosan particles implanted close to the bone marrow degrade in situ in a molecular mass-dependent manner, and attract more stromal cells to the site in aged rabbits compared to the blood clot in untreated controls...

Objective- To investigate the effect of intratendinous injection of bMSCs on the rate and extent of tendon healing after primary repair in a rabbit model. Design- Experimental study. Animals- Twenty seven skeletally mature New Zealand white rabbits weighing 1.8- 2.5 kg were used. Twenty rabbits were used as the experimental animals, and seven others were used as a source of bone marrow-derived ...

Abstract Engineering scaffolds to augment the repair of hard-to-soft multitissue musculoskeletal tissue units, such as bone-tendon, simultaneously support healing and functional movement has had limited success. Overcoming this challenge will require not only precise spatial control bone- tendon-like biomechanical properties, but also consideration resultant cues, well embedded biochemical cues...