the association of osteomalacia with neurofibromatosis is a very rare entity. here a 34 year old man, a known case of neurofibromatosis, is reported who presented with bone pain, hypophosphatemia, rena] phosphorus wasting, multiple looser's pseudofractures, and low bone density. treatment with high dose calcitriol and phosphate resulted in temporary treatment. permanent cure was achieved a...

Bone pain due to skeletal metastases constitutes the most common type of cancer-related pain. The management of bone pain remains challenging and is not standardized. In patients with multifocal osteoblastic metastases, systemic radiopharmaceuticals should be the preferred adjunctive therapy for pain palliation. The lack of general knowledge about radiopharmaceuticals, their clinical utility an...

Background: Fractures occur due to trauma or physical activity with excessive pressure on the bone, including collisions, beatings, falls, irregular tilted positions, dislocations, withdrawals, and abnormal bone weakness (pathological fractures). This study aims analyze effect of Breathing Relaxation spiritual-based reducing pain scale in patients postoperative femoral fractures. Methods: A qua...

Cryoablation is a safe and minimally invasive therapy option that provided rapid durable pain relief, as well an improved quality of life in participants with bone metastases.

introduction: nowadays various bone pain palliative therapeutic agents have been developed for bone metastases. among those, 153sm-ethylenediamine tetramethylene phosphonic acid (153sm-edtmp) is the major therapeutic agent which is widely used in the world. in this study, production, quality control and biodistribution studies of this therapeutic radiopharmaceutical have been presented and foll...

objective(s): recently, bone-avid radiopharmaceuticals have been shown to have potential benefits for the treatment of widespread bone metastases. although 177lutriethylene tetramine hexa methylene phosphonic acid (abbreviated as 177lu- tthmp), as an agent for bone pain palliation, has been evaluated in previous studies, there are large discrepancies between the obtained results. in this study,...

This report is a brief presentation of one case of Oilier's disease. Ollier's disease (multiple enchondromata) patients have widespread involvement of the skeleton, especially the hands the lesions are detected because of bone pain or deformity. Virtually all cases have been sporadic. Roentgenographically, the lesions may be detectable in early infancy as clear, homogeneous, oval lesions w...

BACKGROUND Bone cancer pain is often severe, yet little is known about mechanisms generating this type of chronic pain. While previous studies have identified functional alterations in peripheral sensory neurons that correlate with bone tumours, none has provided direct evidence correlating behavioural nociceptive responses with properties of sensory neurons in an intact bone cancer model. RE...

The cancer-related event that is most disruptive to the cancer patient's quality of life is pain. To begin to define the mechanisms that give rise to cancer pain, we examined the neurochemical changes that occur in the spinal cord and associated dorsal root ganglia in a murine model of bone cancer. Twenty-one days after intramedullary injection of osteolytic sarcoma cells into the femur, there ...

BACKGROUND The Brief Pain Inventory (BPI) and Functional Assessment of Cancer Therapy-Bone Pain (FACT-BP) are commonly used measures of patient reported pain outcomes. We report on the performance of the FACT-BP in comparison to the BPI within a small, randomized trial. METHODS Patients with biochemically defined low risk bone metastases were randomized to 4 weekly (control arm) or 12 weekly ...