نتایج جستجو برای: bone morphogenetic protein
تعداد نتایج: 1505298 فیلتر نتایج به سال:
Bone morphogenetic protein-9 (BMP-9) is a member of the transforming growth factor beta (TGF-β) superfamily of cytokines, which regulate cell growth and differentiation during embryogenesis. Apart of that, the hypoglycemic potential of BMP-9 is of great interest. It has been confirmed that BMP-9, like insulin, improves glycemia in diabetic mice and regulates directional glucose metabolism in he...
Hippo throws its weight behind migrating cells L ucas et al. show that the Hippo pathway helps polarize actin so that groups of Drosophila cells can move in unison. Cells often journey in packs during development and cancer metastasis. In the Drosophila ovary, a group of 4–8 border cells traverses the egg chamber and sidles up to the maturing egg. This maneuver requires adjustments by the actin...
BACKGROUND Acute coronary syndrome is a leading cause of death in developed countries. Follistatin-like 1 (FSTL1) is a myocyte-derived secreted protein that is upregulated in the heart in response to ischemic insult. Here, we investigated the therapeutic impact of FSTL1 on acute cardiac injury in small and large preclinical animal models of ischemia/reperfusion and dissected its molecular mecha...
Runx2/Cbfa1/Pebp2aA is a global regulator of osteogenesis and is crucial for regulating the expression of bone-specific genes. Runx2 is a major target of the bone morphogenetic protein (BMP) pathway. Genetic analysis has revealed that Runx2 is degraded through a Smurf-mediated ubiquitination pathway, and its activity is inhibited by HDAC4. Here, we demonstrate the molecular link between Smurf, ...
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