in this study, based on a biomimetic approach, novel 3d biodegradable porous hybrid scaffolds consisting of chitosan, gelatin, and tricalcium phosphate were developed for bone and cartilage tissue engineering. macroporous chitosan/ gelatin/β-tcp scaffolds were prepared through the process of freeze-gelation/solid-liquid phase separation. the results showed that the prepared scaffolds are highly...

Background: Osteoarthritis (OA) is a progressive, age-associated disease that is characterized with cartilage destruction, subchondral bone remodeling and inflammation of the synovial membrane. Considering the complications of common treatments of OA, including non-steroidal anti-inflammatory drug (NSAIDs) and corticosteroids, investigating new treatments for this disorder is crucial. Recently,...

The non-antigenicity of gelatin was attributed for a long time to its lack of aromatic amino-acids. Later, Landsteiner [1919] and Hooker & Boyd [1932] introduced aromatic determinant groups into the gelatin molecule by coupling it with diazotized arsanilic acid. Injection of arsanil-azo-gelatin into rabbits furnished inmmune sera which gave slight precipitates with the arsanil-azo-compounds of ...

In the current research, preparation and characterization of a series new biocompatible injectable bone paste (IBP) nanocomposites, hydroxyapatite-gelatin (HA-Gel), hydroxyapatite-gelatin-alendronate (HA-Gel-Ald np) are reported. IBP HA-Gel np, were synthesized from mixing different ratios gelatin to aqueous solutions both Ca(NO3)2.4H2O (NH4)2HPO4, while target HA-Gel-Ald obtained by submitting...

Background: In several conditions we have face cranial bone defects. Reconstruction of these defects remains one of the most challenging problems encountered by craniofacial surgeons. Objective: To evaluate bone repair in cranial bone defects by use of an implant made of octacalcium phosphate in combination with bone matrix gelatin (OCP/BMG). Methods: We used 40, 5–6-week-old male Sprague-Dawle...

Abstract Magnesium phosphate-based cements (MPCs) have recently attracted great attention as materials for bone repair. However, the lack of macroporosity, fundamental cells permeation and ingrowth, is one main limitations hampering MPCs full exploitation. In this work gelatin microparticles are exploited templating agents creation macroporosities in MPCs. addition, particles were loaded with a...

Despite of turmeric oleoresin having many advantages over ground turmeric roots, its sensitivity to light, heat and oxygen is a disadvantage. One approach to overcome this problem is microencapsulation. The objective of this work was to investigate the influence of different ratios of maltodextrin/gelatin used as wall materials, as well as the use of ultrasound during the emulsification step on...

Abstract Ariid catfish is a demersal fish species with high production rate. Fishbone by-product protein content converted into gelatin. Gelatin can be utilized as an edible film due to its low water resistance and tensile strength so that suitable polymer needed form good film, namely chitosan tapioca starch. This study aimed determine the effect of on characteristics best formulation ariid bo...

Regeneration of the dura mater following duraplasty using a collagen film, chitosan or combination both with gelatin, was studied in craniotomy and penetrating brain injury model rats. Collagen autofluorescence regenerated evaluated confocal microscopy excitation at λem = 488 nm 543 nm. An increase regeneration extracellular matrix connective tissue an fluorescence were detected 6 weeks after ...

Developing appropriate cell culturing techniques to populate scaffolds has become a great challenge in tissue engineering. This work describes the use of spinner flask dynamic cell cultures to populate hydroxyapatite microcarriers for bone tissue engineering. The microcarriers were obtained through the emulsion of a self-setting aqueous α-tricalcium phosphate slurry in oil. After setting, hydro...