This pilot prospective evaluation study is to verify the efficiency of (18)F-Alfatide II, a specific PET imaging agent for integrin αvβ3, in detecting bone metastasis in human, with comparison to (18)F-FDG PET. Thirty recruited patients underwent (18)F-FDG and (18)F-alfatide II PET/CT successively within days. The final diagnosis of bone lesions was established based on the comprehensive assess...

Benign metastasizing leiomyoma (BML) is composed of well-differentiated smooth muscle cells and dense connective tissue. BML affects middle-aged women who have had previous hysterectomies due to a histologically benign-appearing uterine leiomyoma. We report here on a case of BML from the uterine leiomyoma in a 39-year-old woman that involved the soft tissues, skeletal muscles, lungs and breasts...

The prognosis of osteoarthritis (OA) is worsened by persistent subchondral defects known as bone marrow lesions (BMLs), which herald severe joint degeneration and the need for joint replacement. Joint-preserving treatments that reverse the progression of pain and immobility are limited. Subchondroplasty is a procedure developed to treat BMLs by injecting a calcium phosphate bone substitute into...

BACKGROUND Paget's disease is a condition of focal accelerated bone turnover. Electron-microscopy investigations of osteoclasts from pagetic lesions have identified nuclear inclusion bodies that have a similar appearance to viral nucleocapsid particles. Subsequently, RNA from several paramyxoviruses has been detected in pagetic tissue, and it was suggested that these viruses, in particular meas...

BACKGROUND C3H/HeJ (C3H) mice develop much smaller atherosclerotic lesions than C57BL/6 (B6) mice when deficient in apolipoprotein E (apoE⁻(/)⁻) or fed an atherogenic diet. The 2 strains differ in H2 haplotypes, with B6 having H2(b) and C3H having H2(k). C3.SW-H2(b)/SnJ (C3.SW) is a congenic strain of C3H/HeJ in which H2(k) is replaced with H2(b). METHODS AND RESULTS We performed bone marrow ...

objective(s):sea cucumber derived bioactive compound is considered efficient in treatment of bone disorders. this study was performed   to evaluate the effect of this extract on differentiation of rat bone marrow mesenchymal stem cells (rbmmsc) into osteogenic lineage. materials and methods: isolated rbmmsc were grown in dmem supplemented with 10% fbs. the cells were exposed to different concen...

background: langerhans' cell histiocytosis (lch) is a reactive proliferative disease of unknown pathogenesis characterized by proliferation of langerhans cells. involvement of bone marrow (bm), liver and lung are related to high risk factors and poor survival. the aim of this report is to highlight the clinical and haematological findings of 5 cases of lch with bm infiltration which may help to...

Objective. Multiple extramedullary plasmacytoma lesions involving subcutaneous tissue, breast, mediastinal tissue, spleen, and soft tissue of pelvic region along with multiple bones plasmacytomas without marrow plasmacytosis are a very rare presentation. Design. Case report. Result. A 54-year-old female was found to have multiple small bony lytic lesions, multiple extramedullary soft tissue pla...

The proximal metaphyses of the humerus of weanling gnotobiotic dogs experimentally infected with canine distemper virus (CDV) were investigated histologically and immunocytochemically between 4 and 41 days after infection. Viral antigen was demonstrated in hematopoietic marrow and bone cells at postinfection day (PID) 5 and PID 7, respectively. Between PID 8 and 27, CDV antigen was abundantly p...

to be deemed bone marrow carcinosis. Matrix bone metastases were demonstrated in 78% of patients with bone marrow carcinosis versus only 16% of the patients without bone marrow carcinosis. Heavy tumour infiltration of the bone marrow was associated with multiple bone lesions with histopathologic evidence of bone destruction [5]. This study provided evidence that the primary soil of metastatic b...