Ti-6Al-4V (Ti64) alloy is one of the most widely used orthopedic implant materials due to its mechanical properties, corrosion resistance, and biocompatibility nature. Porous Ti64 structures are gaining more research interest as bone implants they can help in reducing stress-shielding effect when compared their solid counterpart. The literature shows that porous fabricated using different addit...

Abstract Bone lacunae are cavities the morphology of which strongly affects damage propagation inside bone. Nevertheless, role eventual variations in their morphological features is not clear yet. In this scenario, work aims at isolating effects lacunar-like pores on mechanical response 3D printed samples. The research presents a detailed study processability those by means laser powder bed fus...

The ipsilateral and contralateral fibulae have been used as a vascularised bone graft for loss of tibial bone usually by methods which have involved specialised microvascular techniques to preserve or re-establish the blood supply. We have developed a method of tibialisation of the fibula using the Ilizarov fixator system, ipsilateral vascularised fibular transport (IVFT), and have used it in f...

The influence of cycling loading force on the substrate made of frozen bone grafts was investigated. Three layers of bone grafts were compacted in a spherical model of hip joint acetabulum and then subjected to a sinusoidal loading force. For each layer a series of N = 30 loading cycles were performed. The least impacted grafts were located in the upper part of the acetabulum, close to its open...

Disuse by bed rest, limb immobilization or space flight causes rapid bone loss by arresting bone formation and accelerating bone resorption. This net bone loss increases the risk of fracture upon remobilization. Bone loss also occurs in hibernating ground squirrels, golden hamsters, and little brown bats by arresting bone formation and accelerating bone resorption. There is some histological ev...

The purpose of this study was to quantify the levels growth factors (PDGF‐ AB, VEGF, IGF‐1, TGF‐β1) within bone samples at the fusion site of diabetic patients undergoing hindfoot fusion to determine any correlation with successful fusion. Methods The study included 10 adult diabetic subjects from one U.S. center, with an average age of 57.9 years (range 49‐71). Interventions included hindfoot ...

Tissue development and regeneration is regulated by an interplay among various tissue inductive growth factors, formation of an appropriate vascular bed to support the metabolic needs of the forming tissue mass, and a cell population capable of responding to the chemical cues and creating the new tissue. There has been considerable interest in understanding this signaling interplay in bone, due...

This review describes the role of bone cells and their surrounding matrix in maintaining bone strength through the process of bone remodeling. Subsequently, this work focusses on how bone formation is guided by mechanical forces and fluid shear stress in particular. It has been demonstrated that mechanical stimulation is an important regulator of bone metabolism. Shear stress generated by inter...

Australia has experienced a sudden and unexpected resurgence in bed bug infestations from both Cimex lectularius L. and Cimex hemipterus F. A survey in 2006 revealed that infestations had increased across the nation by an average of 4,500% since the start of the decade. In response, a multi-disciplinary approach to combat the rise of this public health pest was implemented and involved the coor...