The important things in designing facilities for BNCT are to obtain neutron beams with appropriate energy spectrum and intensity for efficient treatment. In recent years, at several universities, accelerator-based BNCT facilities were designed, which are composed of target and beam shaping assembly to generate epithermal neutron beams[1]. As a previous study, target system[2][3] and a beam shap...

We have proposed and validated the hamster cheek pouch model of oral cancer for boron neutron capture therapy (BNCT) studies and shown that boronophenylalanine delivers potentially therapeutic 36.9 +/- 17.5 ppm boron to tumor tissue with tumor:normal tissue and tumor:blood ratios of 2.4:1 and 3.2:1, respectively. Here we report the first evidence of the usefulness of BNCT for the treatment of o...

PURPOSE To investigate the efficacy and safety of boron neutron capture therapy (BNCT) in the treatment of inoperable head-and-neck cancers that recur locally after conventional photon radiation therapy. METHODS AND MATERIALS In this prospective, single-center Phase I/II study, 30 patients with inoperable, locally recurred head-and-neck cancer (29 carcinomas and 1 sarcoma) were treated with B...

The purpose of this study was to assess the potential of boron neutron capture therapy (BNCT), with a 6-h infusion of the boron carrier l-boronophenylalanine as a fructose preparation (BPA-f), as first-line radiotherapy for newly diagnosed glioblastoma multiforme (GBM). Patient survival data from a Phase II study using BNCT were compared with retrospective data from the two arms of a Phase III ...

BACKGROUND Boron neutron capture therapy (BNCT) is a unique particle radiation therapy based on the nuclear capture reactions in boron-10. We developed a novel boron-10 containing sodium borocaptate (BSH) derivative, 1-amino-3-fluorocyclobutane-1-carboxylic acid (ACBC)-BSH. ACBC is a tumor selective synthetic amino acid. The purpose of this study was to assess the biodistribution of ACBC-BSH an...

The treatment of malignant brain tumors using conventional therapies and surgery often leads to tumor recurrence and/or unwanted side effects. Boron neutron capture therapy (BNCT) is a binary and localized form of treatment for brain tumors and other difficult-to-treat cancers that uses nontoxic boron-containing agents. Boronated porphyrins and derivatives constitute a class of highly promising...