Mammalian oocytes secrete transforming growth factor β (TGF-β) superfamily proteins, such as growth differentiation factor 9 (GDF9), bone morphogenetic protein 6 (BMP6) and BMP15, and fibroblast growth factors (FGFs). These oocyte-derived paracrine factors (ODPFs) play essential roles in regulating the differentiation and function of somatic granulosa cells as well as the development of ovarian...

This study aimed to examine the polymorphism of BMP15 (FecX$^{G}$ and FecX$^{I}$) GDF9 (G1 G4) genes association between genotypes litter size in Akkaraman breed. Blood samples were taken from 100 ewes total. Genomic DNA was obtained whole blood. The PCR-RFLP technique employed determine polymorphisms under investigation. G1 only polymorphic among four loci analyzed. frequencies for GA GG 0.26 ...

Booroola gene is one of the major genes in the enhancement of ovulation rate and could be an attractive candidate gene for ovulation rate in sheep. Molecular technologies have been widely used for discovery of mutations in animal species. These mutations have major effects on the important economic traits of sheep and goats. This study was conducted to identify the mutation in FecXG region of e...