Monitoring of atypical nevi is an important step in early detection of melanoma, a clinical imperative in preventing the disease progression. Current standard diagnosis is based on biopsy and histopathologic examination, a method that is invasive and highly dependent upon physician experience. In this work, we used a clinical multiphoton microscope to image in vivo and noninvasively melanocytic...

Background: Predilection sites of melanocytic nevi are highly variable; however, individual patterns (e.g. preponderant involvement of extremities, trunk, etc.) are often noticed. A symmetric appearance of nevi on both sides of the body has not been reported. Objective: Guided by an initial, incidental observation of symmetrically arranged plantar nevi, a prospective survey of palmoplantar nevi...

epidermal nevus syndrome is a rare congenital disorder, characterized by epidermal nevi and multiple organ involvement. multicystic kidney disease has been very rarely reported in this syndrome. here is the report of a boy presented with multiple epidermal nevi, cardiac anomaly, seizure attack, hemi hypertrophy, and multicystic dysplastic kidney complicated with wilms' tumor. according to this ...

BACKGROUND It is unclear whether pigmented Spitz and Reed nevi are distinct morphologic entities or part of the spectrum of Spitz nevi. METHODS In a retrospective observational study we analyzed dermatopathologic slides of 22 cases with clinical and dermatoscopic features indicative of pigmented Spitz or Reed nevus in a blinded fashion according to predefined criteria and subsequently correla...

OBJECTIVE To describe the development of nevi from 3 to 8 years of age in a birth cohort of children in Colorado. DESIGN Longitudinal observational study. SETTING Large managed care organization and university and private primary care practices. PARTICIPANTS Annual convenience samples of children born in 1998 (range, n = 137 to n = 870) (participation rates, 18.8%-76.0%). We recruited chi...

Melanocytic nevi are benign melanocyte proliferations. They are well demarcated macula or papilla that may have the same color with the skin or may have reddish-brown, brown, or black color. Melanocytic nevi may be congenital or acquired. In white race, almost every individual have approximately 20 nevi on average (1). In a typical life cycle melanocytic nevi develop after infancy, reach a peak...

BACKGROUND Changes in the clinical appearance of benign dermal nevi during pregnancy may be concerning for malignant transformation. Because the hormonal milieu of pregnancy has not proven to alter their banal behavior, histologic characterization is needed to prevent over-diagnosis and unnecessary treatment. METHODS Dermal nevi excised from pregnant women (n = 16) were compared with nevi fro...

BACKGROUND Atypical nevi are a common risk factor for melanoma. OBJECTIVES The objective was to determine the utility of monitoring dermoscopic photographs of atypical nevi in a high-risk population. METHODS Over a 4.5-year period, digital dermoscopic photographs were taken of clinically atypical nevi at initial and follow-up visits, such that side-by-side comparisons could be made. RESUL...