BACKGROUND AND OBJECTIVES Alternatives to red blood cells transfusion have been studied since the fifties. This study aimed at presenting current status and perspectives of hemoglobin-based blood substitutes. CONTENTS Potential application areas are presented, in addition to clinical studies involving major hemoglobin molecules developed, their advantages and limitations. CONCLUSIONS Severa...

in this study, considering the normal ingredients in guinea pig's milk, by using cow milk, mixture of vitamins and minerals, a milk substitute was prepared and sterilized by autoclaving and filtration methods. in food analysis of produced milk, the important substances values, such as protein, fat and ash, were suitable. milk substitute was fed to four groups of newborn's guinea pigs that we...

New methods to evaluate blood pressure – such as ambulatory blood pressure monitoring (ABPM) and home monitoring of blood pressure (HMBP), have been increasingly more used in clinical practice as key source of additional information to the traditional evaluation of blood pressure measuring at the doctor’s office. There is a growing body of evidence available to show that both methods are strong...

The medical term used for blood pressure is Hypertension (HTN). a common problem faced by most people today. leading danger many diseases such as CVD (cardiovascular) disorder and stroke high pressure. Major like CHF (congestive heart failure), renal disease blindness can also be caused HTN. Awareness of plant-based medication therapeutics continuously increasing day day. Different substitute m...

Regarding research on artificial blood, the “Field of Artificial Blood Development” was inaugurated in 1997, supported by the Ministry of Health and Welfare Grant-in-Aid for Health Science Research, for intensive research activities in the three sub-fields, i.e., artificial red blood cells, artificial platelets, and artificial antibodies. Developed by molecular assembling technology, artificial...

In the final quarter of the 19th century, dissatisfaction with blood transfusion prompted a brief wave of enthusiasm for transfusion of milk as a blood substitute. Although transfusion of cow’s milk wm first attempted in Canada in 1854, this form of treatment achieved its greatest popularity in the United States between 1878 and 1880. During this interval, transfusion of milk from cows, goats a...

OBJECTIVES Hemoglobin vesicles (HbVs) function as a red blood cell (RBC) substitute and are composed of purified hemoglobin encapsulated in a phospholipid bilayer membrane. The performance of HbVs as a substitute for RBC transfusions was examined in a mouse model of pneumonectomy following acute 40% exchange-transfusion with HbVs. METHODS Before performing left pneumonectomies, 40% of the blo...

Eliminating from physiologic circulation a significant amount of unnecessary perfluorocarbons (PFC) is advantageous since little is known about long-term effects of PFC in the circulatory system. The basic circuitry, cell-washer, mechanical manipulations, and overall concept revealed that a significant amount of PFC can be retrieved and estimated in volume and compared to initial volumes. A met...

The immediate effects of treating hemorrhagic shock in dogs by replacing lost blood with 7 per cent hemoglobin solution were favorable, both on renal function and on general condition. However, subsequent transitory depression of the urea clearance for several days, shown by some of the treated animals, but not by untreated bled controls, indicates sufficient possibility of renal damage by the ...