BACKGROUND Halothane is extensively (approximately 50%) metabolized in humans and undergoes both oxidative and reductive cytochrome P450-catalyzed hepatic biotransformation. Halothane is reduced under low oxygen tensions by CYP2A6 and CYP3A4 in human liver microsome to an unstable free radical, and then to the volatile metabolites chlorodifluoroethene (CDE) and chlorotrifluoroethane (CTE). The ...

       The study was designed with an aim to evaluate the protective effects of reduced glutathione on cyclophosphamide induced lipid peroxidation and also changes in cholesterol content. Goat liver and white New Zealand rabbit were used as lipid source for the models. Lipid peroxidation study was performed by measuring the malondial...

semen hyperviscosity (shv) is one of the factors involved in deficiency in sperm function. this research aimed to evaluate seminal plasma total antioxidant capacity (tac) and malondialdehyde (mda) levels in infertile patients with hyperviscous and non-hyperviscous semen samples to understand whether hyperviscous semen is associated with oxidative damage in infertile subjects. in this cross sect...

ferula gummosa boiss is a good source of biologically active compounds such as monoterpene and sesquiterpene derivatives. there are also several reports on antioxidant effects of these compounds. the aim of this study was to investigate the effect of daily administration of f. gummosa root hydro-alcoholic extract on serum oxidant-antioxidant status. twenty four wistar rats were randomly divided...

background: nitric oxide (no) is synthesized from l-arginine by a family of enzymes known as nitric oxide synthases. low concentrations of no is essential in biology and physiology of spermatozoa, but high amounts of no is toxic and has negative effects on sperm functions. moreover, sperm membrane contains high concentrations of polyunsaturated fatty acids that are highly susceptible to oxidati...

This study investigates the effects of tocotrienol-rich palm vitamin E supplementation on exercise-induced lipid peroxidation and endurance performance in the heat. In a double blind, cross-over study, eighteen healthy, male recreational athletes completed two endurance running trials, until exhaustion, on a motorized treadmill at 70% VO2max on two separate occasions following a 6-week suppleme...

Malondialdehyde (MDA) is used for the estimation of damage by reactive oxygen species. MDA is a major reactive aldehyde resulting from the peroxidation of biological membranes. The most common method used to assess MDA production is the thiobarbituric acid (TBARS) assay. However, the value of this method is curbed by low specificity and has been criticized for its use in human studies. In the p...

Background: Giberellic acid is a plant growth regulator,apentacyclicditerpene acid promoting growth and elongation of cells, and also a type of pesticide. In this study its oral administration effect on male rat hormones including gonadotropins (LH and FSH) and testosterone, and also lipid peroxidation product (Malondialdehyde) in testicular tissue was investigated. Materials and Methods: Twent...

objective: type 2 diabetes mellitus is a complex metabolic disorder with adverse cardiovascular risk. chromium (cr) is an essential nutrient and its role in carbohydrate and lipid metabolism has not been clarified especially in iran. the aim of this study was to evaluate the effect of chromium picolinate administration on blood glucose, hba1c, lipid profile and lipid peroxidation in type 2 diab...